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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cell Cycle >Chk inhibitor >PF 477736

PF 477736

PF 477736 Structure
  • ₹12730.2 - ₹51884.23
  • Product name: PF 477736
  • CAS: 952021-60-2
  • MF: C22H25N7O2
  • MW: 419.49
  • EINECS:
  • MDL Number:MFCD16038847
  • Synonyms:PF 477736;PF-00477736;PF-736;(αR)-α-AMino-N-[5,6-dihydro-2-(1-Methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetaMide;PF 477736(PF-0044736);(2R)-2-aMino-2-cyclohexyl-N-[2-(1-Methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7,11-pentaen-6-yl]acetaMide;PF0044736;PF-0044736
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0186
  • Product descriptionPF-477736 ≥98% (HPLC)
  • Packaging5MG
  • Price₹12730.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0186
  • Product descriptionPF-477736 ≥98% (HPLC)
  • Packaging25MG
  • Price₹51884.23
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0186 PF-477736 ≥98% (HPLC) 5MG ₹12730.2 2022-06-14 Buy
Sigma-Aldrich(India) PZ0186 PF-477736 ≥98% (HPLC) 25MG ₹51884.23 2022-06-14 Buy

Properties

Density :1.56
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.79±0.20(Predicted)
color :yellow
InChIKey :NDEXUOWTGYUVGA-LJQANCHMSA-N

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.

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Suppliers and manufacturers

career henan chemical co
PF 477736
₹7.00 /1KG
PF 477736 CAS: 952021-60-2
Wuhan Nutra Biotechnology Co.,Ltd
PF 477736
₹0.00 /1G
PF 477736 CAS:952021-60-2
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