PHA-848125
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- ₹0
- Product name: PHA-848125
- CAS: 802539-81-7
- MF: C25H32N8O
- MW: 460.57
- EINECS:-0
- MDL Number:MFCD17169990
- Synonyms:PHA-848125;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide;Milciclib;PHA-848125 (Milciclib);Milciclib (PHA-848125);N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide PHA 848125;4,5-Dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-pyrazolo[4,3-h]
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Properties
Melting point :190 °C
Density :1.33
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :14.44±0.40(Predicted)
color :Light yellow to yellow
Density :1.33
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :solid
pka :14.44±0.40(Predicted)
color :Light yellow to yellow
Safety Information
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Description
PHA-848125 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) that potently inhibits Cdk2/cyclin A (IC50 = 45 nM). It is at least 3-fold less potent at Cdks 1, 3, 4, 5, and 7. PHA-848125 is orally available and displays efficacy in suppressing the growth of cancer cells or tumor xenografts in animals.Related product price
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