BMS-265246
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- ₹0
- Product name: BMS-265246
- CAS: 582315-72-8
- MF: C18H17F2N3O2
- MW: 345.34
- EINECS:
- MDL Number:MFCD22420825
- Synonyms:BMS-265246;BMS-265246, >=98%;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246;BMS265246; BMS 265246;CS-984;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;BMS-265246 USP/EP/BP
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Properties
Boiling point :552.9±50.0 °C(Predicted)
Density :1.304±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form :solid
pka :8.50±0.40(Predicted)
color :White to pink
Density :1.304±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form :solid
pka :8.50±0.40(Predicted)
color :White to pink
Safety Information
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Description
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. BMS-265246 is a cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin E (IC50s = 6 and 9 nM, respectively). It less potently inhibits Cdk4/cyclin D (IC50 = 0.23 μM). BMS-265246 blocks the cycling of HCT-116 cells (EC50 = 0.29-0.49 μM), resulting in cell cycle arrest in G2 phase.Related product price
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