PULCHINENOSIDE B4
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- Product name: PULCHINENOSIDE B4
- CAS: 129741-57-7
- MF: C59H96O26
- MW: 1221.38
- EINECS:
- MDL Number:MFCD11215450
- Synonyms:PULCHINENOSIDE B4;Anemoside B4 Pulchinenoside B4;Chinensioside A;Pulsatilla saponin B4;Pulchinenoside B4, 98%, from Pulsatilla chinensis (Bunge) Regel;AnemosideB4 129741-57-7;Pulchinenoside C (Anemoside B4);Lup-20(29)-en-28-oic acid, 3-[[2-O-(6-deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxy-, O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester, (3β,4α)-
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Properties
Melting point :208-215℃
Density :1.48
solubility :DMSO : 125 mg/mL (102.34 mM; Need ultrasonic)
form :Powder
pka :12.50±0.70(Predicted)
color :White to light yellow
Density :1.48
solubility :DMSO : 125 mg/mL (102.34 mM; Need ultrasonic)
form :Powder
pka :12.50±0.70(Predicted)
color :White to light yellow
Safety Information
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Description
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.Related product price
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