PUROMYCIN
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- Product name: PUROMYCIN
- CAS: 53-79-2
- MF: C22H29N7O5
- MW: 471.51
- EINECS:
- MDL Number:MFCD00866328
- Synonyms:PUROMYCIN(RG);C01610;PHENYLANTHROLINE Hydrate, 1,10-(RG);AchroMycin, StilloMycin, StyloMycin, CL 13900, 3123L, P638, BacterenoMycin;(s)-3’-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3’-deoxy-n,n-dimethy ;1-mm ;3’-(alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyl-adenosinl ;3’-(l-alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyladenosine
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Properties
Melting point :175.5-177°
alpha :D25 -11° (ethanol)
Boiling point :572.65°C (rough estimate)
Density :1.3119 (rough estimate)
refractive index :1.7010 (estimate)
RTECS :AU7350000
pka :6.8, 7.2(at 25℃)
form :Liquid
Water Solubility :Soluble in water (50 mg/ml at 20°C).
EPA Substance Registry System :Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl- (53-79-2)
alpha :D25 -11° (ethanol)
Boiling point :572.65°C (rough estimate)
Density :1.3119 (rough estimate)
refractive index :1.7010 (estimate)
RTECS :AU7350000
pka :6.8, 7.2(at 25℃)
form :Liquid
Water Solubility :Soluble in water (50 mg/ml at 20°C).
EPA Substance Registry System :Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl- (53-79-2)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.More related product prices
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