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Picotamide

Picotamide Structure
  • ₹24410.38
  • Product name: Picotamide
  • CAS: 32828-81-2
  • MF: C21H20N4O3
  • MW: 376.41
  • EINECS:251-245-7
  • MDL Number:MFCD00866792
  • Synonyms:4-METHOXY-N,N'-BIS(3-PYRIDINYLMETHYL)-1,3-BENZENEDICARBOXAMIDE;PICOTAMIDE;4-methoxy-n,n’-bis(3-pyridylmethyl)-isophthalamid ;4-methoxy-n,n’-bis(3-pyridylmethyl)isophthalamide ;g137 ;n,n’-bis(3-picolyl)-4-methoxyisophthalamide ;n,n’-bis(3-pyridinylmethyl)-4-methoxy-1,3-benzenedicarboxamide ;n,n’-bis(3-pyridinylmethyl)-4-methoxy-3-benzenedicarboxamide
1 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP8477
  • Product descriptionPicotamide
  • Packaging5MG
  • Price₹24410.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P8477 Picotamide 5MG ₹24410.38 2022-06-14 Buy

Properties

Melting point :128-131℃
Boiling point :668.1±55.0 °C(Predicted)
Density :1.246±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
pka :13.31±0.46(Predicted)
form :White solid.
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Precautionary statements:
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P403 Store in a well-ventilated place.

Description

Picotamide is a dually active TXA2R (thromboxane A2) and TXA synthase (thromboxane A2 synthase) inhibitor. It has been shown to exhibit platelet inhibitory effects ex vivo and in vitro. It suppresses arachidonic acid, low-dose collagen, and TXA2-induced human platelet aggregation. However, it does not afftect A23187 induced aggregation or primary aggregation by ADP. It has been shown to inhibit the synthesis of TXA2 by platelets in a dose dependent fashion. It has been reported to enhance PGE2 formation, and enhance PGI2 formation by aspirinated endothelial cells. It has also been shown to raise intraplatelet cAMP levels in platelets stimulated with arachidonic acid.

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