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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >Posaconazole

Posaconazole

Posaconazole Structure
  • ₹3600 - ₹53854.38
  • Product name: Posaconazole
  • CAS: 171228-49-2
  • MF: C37H42F2N8O4
  • MW: 700.78
  • EINECS:682-747-8
  • MDL Number:MFCD00941162
  • Synonyms:4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-hydroxypentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one;Posaconazole(Form Ⅲ);Posaconazole ;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Sch 56592;HYDROXYPROPYL]-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE;Posaconazole for research;1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • 1ML
  • ManufacturerTCI Chemicals (India)
  • Product numberP2477
  • Product descriptionPosaconazole
  • Packaging10MG
  • Price₹3600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberP2477
  • Product descriptionPosaconazole
  • Packaging50MG
  • Price₹12100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number32103
  • Product descriptionPosaconazole VETRANAL?, analytical standard
  • Packaging25MG
  • Price₹11236.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2287
  • Product descriptionPosaconazole ≥98% (HPLC)
  • Packaging5MG
  • Price₹13390.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP-103
  • Product descriptionPosaconazole solution 2.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹16425.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML2287
  • Product descriptionPosaconazole ≥98% (HPLC)
  • Packaging25MG
  • Price₹53854.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) P2477 Posaconazole 10MG ₹3600 2022-05-26 Buy
TCI Chemicals (India) P2477 Posaconazole 50MG ₹12100 2022-05-26 Buy
Sigma-Aldrich(India) 32103 Posaconazole VETRANAL?, analytical standard 25MG ₹11236.35 2022-06-14 Buy
Sigma-Aldrich(India) SML2287 Posaconazole ≥98% (HPLC) 5MG ₹13390.53 2022-06-14 Buy
Sigma-Aldrich(India) P-103 Posaconazole solution 2.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹16425.5 2022-06-14 Buy
Sigma-Aldrich(India) SML2287 Posaconazole ≥98% (HPLC) 25MG ₹53854.38 2022-06-14 Buy

Properties

Melting point :170-1720C
Boiling point :850.7±75.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
Flash point :9℃
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :14.72±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D -24 to -32°, c = 1.0 in chloroform-d
Merck :14,7602
InChIKey :RAGOYPUPXAKGKH-XAKZXMRKSA-N
SMILES :[C@]1(OC[C@@H](COC2C=CC(N3CCN(C4=CC=C(N5C=NN([C@@H](CC)[C@@H](O)C)C5=O)C=C4)CC3)=CC=2)C1)(CN1N=CN=C1)C1=CC=C(F)C=C1F |&1:0,3,22,25,r|
CAS DataBase Reference :171228-49-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Posaconazole is a broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Posaconazole inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase enzyme (IC50s range from 7-200 nM), which results in a disruption the synthesis of ergosterol, a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins.

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Suppliers and manufacturers

Dr. Reddy's Laboratories Ltd SGMR PHARMACEUTICALS PVT LTD SEUTIC Prajna generics pvt ltd Metrochem API Private Limited Apotex Pharmachem India Pvt Ltd Honour Lab Limited Hetero Drugs Limited Bajaj Healthcare Ltd Om Pharmaceutical Industries