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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Thyroid hormone and antithyroid drugs >REVERSE T3

REVERSE T3

REVERSE T3 Structure
  • ₹13898.5
  • Product name: REVERSE T3
  • CAS: 5817-39-0
  • MF: C15H12I3NO4
  • MW: 650.97
  • EINECS:621-265-4
  • MDL Number:MFCD00036864
  • Synonyms:Reverse T3 (3,3',5'-Triiodo-L-Thyronine);L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-;REVERSE T3;L-3,3',5'-TRIIODOTHYRONINE;3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution;Levothyroxine EP Impurity K;3,3',5'-TRIIODO-L-THYRONINE, THYROID;Reverse L-triiodothyronine
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Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberT-075
  • Product description3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹13898.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T-075 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹13898.5 2022-06-14 Buy

Properties

Melting point :234-238 °C(lit.)
Boiling point :534.6±50.0 °C(Predicted)
Density :2.387±0.06 g/cm3(Predicted)
Flash point :9℃
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :powder
pka :2.17±0.20(Predicted)
color :Pale Beige to Brown
Stability :Light Sensitive
InChI :InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey :HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES :C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Description

3,3',5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine and commonly described as inactive. However, high serum levels of rT3 are found in neonates and in certain conditions. It reportedly activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.

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