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Ramatroban

Ramatroban Structure
  • ₹16908.65 - ₹65112.38
  • Product name: Ramatroban
  • CAS: 116649-85-5
  • MF: C21H21FN2O4S
  • MW: 416.47
  • EINECS:
  • MDL Number:MFCD00887606
  • Synonyms:BAY-U3405;3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID;(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid;3-[(3R)-3-(4-Fluorophenylsulfonylamino)-1,2,3,4-tetrahydro-9H-carbazole-9-yl]propionic acid;(R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid;RAFFINOSE UNDECAACETATE, D-(+)-(RG);(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid;RaMatroban(BAY-u3405)
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberR0531
  • Product descriptionRamatroban ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹16908.65
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR0531
  • Product descriptionRamatroban ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹65112.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) R0531 Ramatroban ≥98% (HPLC), solid 5MG ₹16908.65 2022-06-14 Buy
Sigma-Aldrich(India) R0531 Ramatroban ≥98% (HPLC), solid 25MG ₹65112.38 2022-06-14 Buy

Properties

Melting point :134-135°
alpha :D +70.1° (c = 1.0 in methanol)
Boiling point :654.7±65.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥40mg/mL
form :solid
pka :4.60±0.10(Predicted)
color :white
CAS DataBase Reference :116649-85-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The biological effects of prostaglandin D2 (PGD2; ) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2. BAY-u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor). BAY-u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM. BAY-u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY-u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type.

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