Relugolix
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- ₹0
- Product name: Relugolix
- CAS: 737789-87-6
- MF: C29H27F2N7O5S
- MW: 623.63
- EINECS:237-099-7
- MDL Number:MFCD25976856
- Synonyms:TAK-385;TKA-385 Relugolix;TAK-385,Relugolix;CS-2851;TAK-385;TAK 385;TAK385;1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(dimethylamino)methyl]-3-(6-methoxypyridazin-3-yl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea;10G,100G,500G,1KG;N-[4-[1-[(2,6-Difluorophenyl)methyl]-5-[(dimethylamino)methyl]-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy urea
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Properties
Melting point :228 °C (decomp)(Solv: ethyl acetate (141-78-6); tetrahydrofuran (109-99-9))
Density :1.442±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:20.0(Max Conc. mg/mL);32.1(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);1.6(Max Conc. mM) form :A crystalline solid
pka :13.17±0.70(Predicted)
color :White to off-white
InChIKey :AOMXMOCNKJTRQP-UHFFFAOYSA-N
SMILES :N(C1=CC=C(C2SC3=C(C=2CN(C)C)C(=O)N(C2=NN=C(OC)C=C2)C(=O)N3CC2=C(F)C=CC=C2F)C=C1)C(NOC)=O
Density :1.442±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:20.0(Max Conc. mg/mL);32.1(Max Conc. mM)
Ethanol:1.0(Max Conc. mg/mL);1.6(Max Conc. mM) form :A crystalline solid
pka :13.17±0.70(Predicted)
color :White to off-white
InChIKey :AOMXMOCNKJTRQP-UHFFFAOYSA-N
SMILES :N(C1=CC=C(C2SC3=C(C=2CN(C)C)C(=O)N(C2=NN=C(OC)C=C2)C(=O)N3CC2=C(F)C=CC=C2F)C=C1)C(NOC)=O
Safety Information
Symbol(GHS): |
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Signal word: | Warning | ||||||||||||||||||||||
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Description
Relugolix (TAK-385) is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. It possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.More related product prices
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