Rosuvastatin
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- Product name: Rosuvastatin
- CAS: 287714-41-4
- MF: C22H28FN3O6S
- MW: 481.54
- EINECS:689-191-5
- MDL Number:MFCD08460959
- Synonyms:7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;ROSUVASTATIN-D3 SODIUM SALT;(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid;(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid;R-2: TERT-BUTYL-(+) 7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYLSULFONYLAMINO) PYRIMIDINE-5-YL]-(3R, 5S)-DIOXANE-(E)-6-HEPTENATE;Rosuvastatin;Rosuvastatin Impurity 21;CS-111
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Properties
Melting point :161.9 °C
Boiling point :745.6±70.0 °C(Predicted)
Density :1.368±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :Solid
pka :4.25±0.10(Predicted)
color :White to Pale Beige
BCS Class :3
CAS DataBase Reference :287714-41-4(CAS DataBase Reference)
EPA Substance Registry System :6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)- (287714-41-4)
Boiling point :745.6±70.0 °C(Predicted)
Density :1.368±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form :Solid
pka :4.25±0.10(Predicted)
color :White to Pale Beige
BCS Class :3
CAS DataBase Reference :287714-41-4(CAS DataBase Reference)
EPA Substance Registry System :6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)- (287714-41-4)
Safety Information
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Description
Rosuvastatin is a highly efficacious statin that is more potent in reducing LDL cholesterol and triglycerides and in raising HDL cholesterol than the other statins discussed.It appears to combine a number of the characteristics of the currently available statins. Like pravastatin, rosuvastatin is liver-selective, hydrophilic, and minimally metabolized via CYP3A4. Like atorvastatin, rosuvastatin has a prolonged half-life in systemic plasma of about 20 hours and is quite potent. The maximum tested dose of 80 mg reduced LDL 65%, significantly more than is possible using current monotherapy; however, the high dose was not well tolerated in some patients. Rosuvastatin also produced greater increases in HDL than is seen with high-dose atorvastatin. The 10 mg dose reduced LDL by approximately 50%.More related product prices
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