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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiepileptic and anticonvulsant >(S)-MEPHENYTOIN

(S)-MEPHENYTOIN

(S)-MEPHENYTOIN Structure
  • ₹0
  • Product name: (S)-MEPHENYTOIN
  • CAS: 50-12-4
  • MF: C12H14N2O2
  • MW: 218.25
  • EINECS:200-012-8
  • MDL Number:MFCD00270025
  • Synonyms:(S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE;(S)-(+)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN;(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN;(S)-(+)-MEPHENYTOIN;(+/-)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE;(+/-)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN;(+/-)-MEPHENYTOIN;MEPHENYTOIN
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :135-138 °C
Boiling point :358.94°C (rough estimate)
Density :1.154±0.06 g/cm3 (20 ºC 760 Torr)
refractive index :1.6660 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form :solid
pka :pKa 8.1 (Uncertain)
color :off-white
CAS DataBase Reference :50-12-4(CAS DataBase Reference)
EPA Substance Registry System :Mephenytoin (50-12-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.

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Voriconazole (S)-MEPHENYTOIN 5-Phenylhydantoin 631-07-2

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Suppliers and manufacturers

Dideu Industries Group Limited
(S)-MEPHENYTOIN USP/EP/BP
₹1.10 /1g
(S)-MEPHENYTOIN USP/EP/BP CAS:50-12-4
CLEARSYNTH LABS LTD.
TargetMol Chemicals Inc.
Alfa Chemistry
InvivoChem
Shaanxi Didu New Materials Co. Ltd
Nantong HI-FUTURE Biology Co., Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd Shandong Mopai Biotechnology Co., Ltd Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd