SWAINSONINE
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- ₹17341.65 - ₹50412.03
- Product name: SWAINSONINE
- CAS: 72741-87-8
- MF: C8H15NO3
- MW: 173.21
- EINECS:
- MDL Number:MFCD00017554
- Synonyms:8-indolizinetriol,octahydro-,(1s,2r,8r,8ar)-2 ;(1S,2S,8R,8AR)-TRIHYDROXYINDOLIZIDINE;(1S,2R,8R,8AR)-1,2,8-OCTAHYDROINDOLIZIDINETRIOL;8ALPHA,BETA-INDOLIZIDINE-1,2ALPHA,8BETA-TRIOL;8ALPHA,BETA-INDOLIZIDINE-1ALPHA,2ALPHA,8BETA-TRIOL;8A-BETA-INDOLIZIDINE-1ALPHA,2ALPHA,8BETA-TRIOL;8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;8A,B-OCTAHYDROINDOLIZIDINE-1A,2A,8B-TRIOL
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 0.1MG
- 0.5MG
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product numberS9263
- Product descriptionSwainsonine synthetic
- Packaging0.1MG
- Price₹17341.65
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS8195
- Product descriptionSwainsonine from Metarrhizium anisopliae, ≥98% (TLC)
- Packaging1MG
- Price₹24388.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS9263
- Product descriptionSwainsonine synthetic
- Packaging0.5MG
- Price₹50412.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S9263 | Swainsonine synthetic | 0.1MG | ₹17341.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S8195 | Swainsonine from Metarrhizium anisopliae, ≥98% (TLC) | 1MG | ₹24388.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S9263 | Swainsonine synthetic | 0.5MG | ₹50412.03 | 2022-06-14 | Buy |
Properties
Melting point :148-149°C
Boiling point :353.3±21.0 °C(Predicted)
Density :1.38±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :H2O: soluble1mg/mL
pka :14.01±0.60(Predicted)
form :lyophilized powder
color :white to faint yellow
Water Solubility :Soluble to 50 mM in water
BRN :4175740
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :72741-87-8
Boiling point :353.3±21.0 °C(Predicted)
Density :1.38±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :-20°C
solubility :H2O: soluble1mg/mL
pka :14.01±0.60(Predicted)
form :lyophilized powder
color :white to faint yellow
Water Solubility :Soluble to 50 mM in water
BRN :4175740
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference :72741-87-8
Safety Information
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Description
Swainsonine is an indolizidine alkaloid naturally found in certain plants including locoweed that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins. It reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM). Swainsonine is used to study the role of N-linked glycosylation in cellular processes and has been shown to have antiproliferative and antimetastatic effects of cancer cells in culture and in mice. The inhibition of α-mannosidase activity in lysosomes produces an accumulation of partially-processed oligosaccharides and glycoproteins, giving rise to lysosomal storage disease. Swainsonine toxicity in herbivores results in a condition known as locoism, characterized by hyperactivity, aggression, stiff and clumsy gait, low head carriage, salivation, seizures, and apparent blindness, culminating in increased miscoordination, weakness and death.More related product prices
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