Scutellarin
- ₹34899.8
- Product name: Scutellarin
- CAS: 27740-01-8
- MF: C21H18O12
- MW: 462.36
- EINECS:1806241-263-5
- MDL Number:MFCD01861503
- Synonyms:SCUTELLARIN, 98+% BY HPLC;(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl;β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2-;4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone;4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid;5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid;Scutellarein 4'-methyl ether 7-glucuronide;Scutellarein 7-glucuronide
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Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number73577
- Product descriptionScutellarin analytical standard
- Packaging10MG
- Price₹34899.8
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 73577 | Scutellarin analytical standard | 10MG | ₹34899.8 | 2022-06-14 | Buy |
Properties
Melting point :300~301℃
Boiling point :891.6±65.0 °C(Predicted)
Density :1.810±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Very Slightly, Sonicated)
pka :2.72±0.70(Predicted)
form :Solid
color :Light Yellow to Yellow
BRN :71779
CAS DataBase Reference :27740-01-8(CAS DataBase Reference)
Boiling point :891.6±65.0 °C(Predicted)
Density :1.810±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO (Slightly), Methanol (Very Slightly, Sonicated)
pka :2.72±0.70(Predicted)
form :Solid
color :Light Yellow to Yellow
BRN :71779
CAS DataBase Reference :27740-01-8(CAS DataBase Reference)
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Description
Scutellarin is a flavone that has been found in S. barbata and has diverse biological activities, including anticancer, lipid lowering, antioxidative, and neurocognitive properties. It inhibits proliferation of PC-9 and H1975 non-small cell lung cancer (NSCLC) cells in a concentration-dependent manner and induces apoptosis and autophagy when used at a concentration of 160 μM, effects that can be blocked by the autophagy inhibitor HCQ . Scutellarin (30 and 60 mg/kg per day) reduces tumor growth in an H1975 mouse xenograft model. It decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease (NAFLD) when administered at doses of 25 and 50 mg/kg. It decreases hepatic malondialdehyde (MDA), glutamic-oxalacetic transaminase (GOT), and glutamic-pyruvic transaminase (GPT) activity, increases catalase (CAT) and total antioxidative capacity (T-AOC) activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in the same model. Scutellarin (5, 25, and 50 mg/kg per day) also prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively.More related product prices
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