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Tipiracil

Tipiracil Structure
  • ₹15451.2 - ₹64590.9
  • Product name: Tipiracil
  • CAS: 183204-72-0
  • MF: C9H12Cl2N4O2
  • MW: 279.12318
  • EINECS:
  • MDL Number:MFCD01571384
  • Synonyms:Tipiracil;Tipiracil (hydrochloride);2,4(1H,3H)-PyriMidinedione,5-chloro-6-[(2-iMino-1-pyrrolidinyl)Methyl] hydrochloride;5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione monohydrochloride;Tipiracil HCl;5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione,hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride;5-Chloro-6-(2-iminopyrrolidin-1-ylmethyl)uracil hydrochloride
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1552
  • Product descriptionTipiracil hydrochloride ≥98% (HPLC)
  • Packaging10MG
  • Price₹15451.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1552
  • Product descriptionTipiracil hydrochloride ≥98% (HPLC)
  • Packaging50MG
  • Price₹64590.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1552 Tipiracil hydrochloride ≥98% (HPLC) 10MG ₹15451.2 2022-06-14 Buy
Sigma-Aldrich(India) SML1552 Tipiracil hydrochloride ≥98% (HPLC) 50MG ₹64590.9 2022-06-14 Buy

Properties

Melting point :245℃ (decomposition)
storage temp. :2-8°C
solubility :DMSO (Slightly, Heated), Water (Slightly)
form :powder
color :white to beige
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Tipiracil (TPI) is a potent and competitive inhibitor of thymidine phosphorylase (TPase) with an IC50 value of 35 nM for human placental TPase. It is selective for TPase over other pyrimidine-metabolizing enzymes (IC50s = >1 mM for UPase, OPRTase, TK, and DPDase). TPI inhibits the phosphorolysis and degradation of trifluorothymidine , a cytotoxic nucleoside, in human breast and colon carcinoma tumor samples. Oral administration of TPI (12.5-50 mg/kg) enhances the anti-tumor activity of trifluorothymidine in a mouse AZ-521 stomach cancer xenograft model. Formulations containing TPI have been used for the treatment of metastatic colorectal cancer.

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Biophore India Pharmaceuticals Pvt Ltd Hetero Drugs Limited AUROBINDO PHARMA LTD INTAS PHARMACEUTICALS LTD MSN LABORATORIES PRIVATE LTD BIOPHORE INDIA PHARMACEUTICALS PVT LTD CLEARSYNTH LABS LTD. A.J Chemicals
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED