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UNC-0642

UNC-0642 Structure
  • ₹21078.9 - ₹85370.1
  • Product name: UNC-0642
  • CAS: 1481677-78-4
  • MF: C29H44F2N6O2
  • MW: 546.7
  • EINECS:
  • MDL Number:MFCD28044322
  • Synonyms:UNC 0642;UNC0642;UNC-0642;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;UNC0642, 2-(4,4-Difluoro-1-piperidinyl)-6-Methoxy-N-[1-(1-Methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinaMine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;UNC-0642;UNC0642;UNC 0642
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1037
  • Product descriptionUNC0642 ≥98% (HPLC)
  • Packaging25MG
  • Price₹85370.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1037
  • Product descriptionUNC0642 ≥98% (HPLC)
  • Packaging5MG
  • Price₹21078.9
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1037 UNC0642 ≥98% (HPLC) 25MG ₹85370.1 2022-06-14 Buy
Sigma-Aldrich(India) SML1037 UNC0642 ≥98% (HPLC) 5MG ₹21078.9 2022-06-14 Buy

Properties

Boiling point :679.2±65.0 °C(Predicted)
Density :1.23±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
pka :10.06±0.20(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferases G9a and G9a-like protein (GLP) can mono- or dimethylate lysine 9 on histone 3, contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0642 is a selective inhibitor of G9a and GLP that competitively inhibits binding of H3K9 substrates with a Ki = 3.7 nM. It exhibits >2,000-fold selectivity over the lysine methyltransferase EZH2 and >20,000-fold selectivity over other methyltransferases. UNC0642 has been shown to reduce H3K9 dimethylation levels in MDA-MB-231 and PANC-1 cells with IC50 values of 110 and 40 nM, respectively. Furthermore, it displays improved pharmacokinetic properties relative to UNC0638 . See the Structural Genomics Consortium (SGC) website for more information.

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