UNC2881
- ₹0
- Product name: UNC2881
- CAS: 1493764-08-1
- MF: C25H33N7O2
- MW: 463.58
- EINECS:
- MDL Number:MFCD28142814
- Synonyms:2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide;UNC2881;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide;N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;110849;UNC 2881; UNC-2881;CS-1177
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Properties
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form :solid
pka :12.70±0.46(Predicted)
color :White to off-white
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form :solid
pka :12.70±0.46(Predicted)
color :White to off-white
Safety Information
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Description
UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.More related product prices
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