UNC2250
- ₹0
- Product name: UNC2250
- CAS: 1493694-70-4
- MF: C24H36N6O2
- MW: 440.58
- EINECS:
- MDL Number:MFCD27992060
- Synonyms:(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;UNC2250;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250;CS-1346;UNC2250(UNC 2250);4-[[2-(butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-ol;Cyclohexanol, 4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-, trans-
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :207-210oC
Boiling point :657.4±65.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :15.02±0.40(Predicted)
color :Pale Yellow to Yellow
Boiling point :657.4±65.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :15.02±0.40(Predicted)
color :Pale Yellow to Yellow
Safety Information
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Description
Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.More related product prices
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