XL765
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- ₹0
- Product name: XL765
- CAS: 1349796-36-6
- MF: C31H29N5O6S
- MW: 599.66
- EINECS:
- MDL Number:MFCD18252649
- Synonyms:SAR245409 (XL765);PI3K-IN-1;N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;Benzamide, N-[4-[[[3-[(3,5-dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methyl-;Voxtalisib (SAR245409, XL765);N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide SAR245409 (XL765);XL765 N-[4-[[[3-[(3,5-Dimethoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-3-methoxy-4-methylbenzamide;N-(4-(N-(3-((3,5-Dimethoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-3-methoxy-4-methylben
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.387±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form :solid
pka :5.88±0.30(Predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15 mg/mL in DMSO
form :solid
pka :5.88±0.30(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) constitutively signal and drive cell survival and proliferation in many forms of cancer. XL765 is a dual inhibitor of both PI3K and mTOR, completely blocking phosphorylation of substrates at 8-16 μM. Similarly, XL765 is cytotoxic to glioblastoma multiforme (GBM) xenografts in vitro, with half maximal inhibition occurring at 3.7-7.7 μM. XL765 is orally bioavailable and passes the blood-brain barrier, reducing the growth of intracranial GBM xenografts in mice. This inhibitor is effective alone or in combination therapy with other compounds in various types of cancer.Related product price
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