YM 26734

₹13563.73 - ₹54547.18
Product name: YM 26734
CAS: 144337-18-8
MF: C45H62O8
MW: 730.97
EINECS:
MDL Number:MFCD00918068
Synonyms:YM 26734;1-Dodecanone, 1,1'-(5-(3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl)-2,4,6-trihydroxy-1,3-phenylene)bis-;4-(3,5-Didodecanoyl-2,4,6-trihydroxyphenyl)-7-hydroxy-2-(4-hydroxyphenyl)chroman;1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone;1-[3-dodecanoyl-2,4,6-trihydroxy-5-[7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]phenyl]dodecan-1-one

Price2 Properties Safety Information Description

2 prices

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Brand

Sigma-Aldrich(India)

Package

5MG
25MG

ManufacturerSigma-Aldrich(India)
Product numberSML1226
Product descriptionYM-26734 ≥95% (HPLC)
Packaging5MG
Price₹13563.73
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSML1226
Product descriptionYM-26734 ≥95% (HPLC)
Packaging25MG
Price₹54547.18
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML1226	YM-26734 ≥95% (HPLC)	5MG	₹13563.73	2022-06-14	Buy
Sigma-Aldrich(India)	SML1226	YM-26734 ≥95% (HPLC)	25MG	₹54547.18	2022-06-14	Buy

Properties

storage temp. :Store at -20°C
solubility :Soluble to 100 mM in DMSO and to 100 mM in ethanol
form :Powder

Safety Information

Symbol(GHS):

Signal word:

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes

Precautionary statements:

Description

Secreted phospholipases A2 (sPLA2s) are a diverse family of low molecular weight PLA2s with tissue-specific expression patterns and actions. The group IIA sPLA2 (sPLA2-IIA) was originally purified from platelets and exudates from patients with rheumatoid arthritis. Its expression can be induced by inflammatory mediators, and mouse studies suggest that it may play roles in colorectal polyposis, atherosclerosis, and bacterial infections. YM-26734 is a derivative of a compound isolated from the fruit of H. amygdaline that competitively inhibits rabbit platelet sPLA2 with an IC50 value of 85 nM. It inhibits sPLA2-hGIIA, -mGIIA, -rGIIA, -hGV, -mGV, -hGX, and -mGX with IC50 values of 80, 30, 120, 110, 520, >1600, and >1600 nM, respectively. YM-26734 displays minimal activity at cytosolic PLA2, COX and lipoxygenase. At 45 μg/ear or 11 mg/kg i.v., YM-26734 has been used to ameliorate local inflammatory responses in TPA-induced mouse ear edema.

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