YM155
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- ₹0
- Product name: YM155
- CAS: 781661-94-7
- MF: C20H19BrN4O3
- MW: 443.29386
- EINECS:-0
- MDL Number:MFCD11983133
- Synonyms:YM155;4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide;SepantroniuM broMide;SepantroniuM broMide(YM155,YM-155);Sepantronium Bromide (YM155);1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1);4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide YM 155;YM 155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Melting point :>180°C (dec.)
storage temp. :-20°
solubility :Soluble in DMSO (up to 25 mg/ml).
form :solid
color :Tan to yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :-20°
solubility :Soluble in DMSO (up to 25 mg/ml).
form :solid
color :Tan to yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter. It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM. At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins. YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.Related product price
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