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ChemicalBook > Product Catalogue >Analytical Chemistry >Analysis reagents >Ion chromatography reagents >Afimoxifene

Afimoxifene

Afimoxifene Structure
  • ₹10229.63 - ₹42812.88
  • Product name: Afimoxifene
  • CAS: 68392-35-8
  • MF: C26H29NO2
  • MW: 387.51
  • EINECS:
  • MDL Number:
  • Synonyms:AFIMOXIFENE;4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol;4-Hydroxytamoxifen, (E)-isomer;4-Hydroxytamoxifen, (Z)-isomer;4-Monohydroxytamoxifen;4-Oht hydrotamoxifen;C016601;(E/Z)-4-Hydroxy Tamoxifen
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberH6278
  • Product description4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer)
  • Packaging10MG
  • Price₹10229.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT176
  • Product description4-Hydroxytamoxifen analytical standard, (E) and (Z) isomers (50:50)
  • Packaging10MG
  • Price₹10825
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number94873
  • Product description4-Hydroxytamoxifen (E) and (Z) isomers (50:50), analytical standard
  • Packaging10MG
  • Price₹16118.43
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1666
  • Product description4-Hydroxytamoxifen Ready Made Solution 5?mg/mL in ethanol: isopropanol (95:5)
  • Packaging1ML
  • Price₹16359
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH6278
  • Product description4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer)
  • Packaging50MG
  • Price₹30775.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT176
  • Product description4-Hydroxytamoxifen analytical standard, (E) and (Z) isomers (50:50)
  • Packaging50MG
  • Price₹42812.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) H6278 4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer) 10MG ₹10229.63 2022-06-14 Buy
Sigma-Aldrich(India) T176 4-Hydroxytamoxifen analytical standard, (E) and (Z) isomers (50:50) 10MG ₹10825 2022-06-14 Buy
Sigma-Aldrich(India) 94873 4-Hydroxytamoxifen (E) and (Z) isomers (50:50), analytical standard 10MG ₹16118.43 2022-06-14 Buy
Sigma-Aldrich(India) SML1666 4-Hydroxytamoxifen Ready Made Solution 5?mg/mL in ethanol: isopropanol (95:5) 1ML ₹16359 2022-06-14 Buy
Sigma-Aldrich(India) H6278 4-Hydroxytamoxifen ≥70% Z isomer (remainder primarily E-isomer) 50MG ₹30775.48 2022-06-14 Buy
Sigma-Aldrich(India) T176 4-Hydroxytamoxifen analytical standard, (E) and (Z) isomers (50:50) 50MG ₹42812.88 2022-06-14 Buy

Properties

Melting point :135-144°C
Boiling point :514.4±50.0 °C(Predicted)
Density :1.092
storage temp. :2-8°C
solubility :methanol: soluble10mg/mL
form :solution
pka :9.38±0.15(Predicted)
color :white to off-white

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Tamoxifen is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. ?(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen that is formed by the action of cytochrome P450 2D6 in human liver. It exhibits more potent estrogen agonist/antagonist activity than its parent compound and can inhibit MCF-7 and MDA-MB-231 cell proliferation with IC50 values of 27 and 18 μM, respectively. ?(E/Z)-4-hydroxy Tamoxifen has been used to stimulate LC3 lipidation and formation of autophagic vesicles in a superoxide-dependent manner.

More related product prices

Phenol DIETHOXYMETHANE Tamoxifen citrate 4-Ethoxyphenol Nonylphenol Chlorodimethylphenylsilane 2-Phenylphenol 4-Aminophenol Phenylhydrazine 4-Phenylphenol Tamoxifen 2-Ethoxyphenol Phenol Red Ethoxyquin 4-HYDROXYTAMOXIFEN Droloxifene 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine (E)-4-Acetoxy Tamoxifen TAMOXIFEN-N-OXIDE

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