TAMOXIFEN-N-OXIDE
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- Product name: TAMOXIFEN-N-OXIDE
- CAS: 75504-34-6
- MF: C26H29NO2
- MW: 387.51
- EINECS:
- MDL Number:MFCD00869497
- Synonyms:TAMOXIFEN-N-OXIDE;(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine-N-oxide;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, N-oxide, (Z)-;Tamoxifen epoxide;2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine N-oxide;Ethanamine, 2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl-, N-oxide;Tamoxifen Citrate Impurity 12 (Tamoxifen N-oxide)
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Properties
storage temp. :Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility :DMF: 20 mg/mL; DMSO: 2 mg/mL; Ethanol: 20 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
form :A crystalline solid
pka :4.49±0.40(Predicted)
color :White to off-white
solubility :DMF: 20 mg/mL; DMSO: 2 mg/mL; Ethanol: 20 mg/mL; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/mL
form :A crystalline solid
pka :4.49±0.40(Predicted)
color :White to off-white
Safety Information
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Description
Tamoxifen is a selective estrogen receptor modulator that evokes tissue-dependent effects. Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases. It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin. Like the parent compound, tamoxifen N-oxide can form DNA adducts. Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 μM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively).More related product prices
4-HYDROXYTAMOXIFEN 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine (E)-4-Acetoxy Tamoxifen Droloxifene Endoxifen 4Hydroxy Tamoxifen N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) TaMoxifen DiMer 4-Benzyloxy β-Hydroxy TaMoxifen N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) 15917-65-4 Tamoxifen citrate Afimoxifene (Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)-1-butene (E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen N-METHYL-N-(2-HYDROXYETHYL)TAMOXIFEN TamoxifenRelated product price
- 4-HYDROXYTAMOXIFEN
₹9380-60013.8 - 15917-65-4
₹28123.35 - Tamoxifen citrate
₹5880-128709.25
Suppliers and manufacturers
CLEARSYNTH LABS LTD.
Pharmaffiliates Analytics and Synthetics P. Ltd
Shenzhen Excellent Biomedical Technology Co.,Ltd.
Shenzhen Excellent Biomedical Technology Co., Ltd.
Cayman Chemical Company
Shanghai Yifei Biotechnology Co. , Ltd.
BOC Sciences
Nantong Hanfang Biotechnology Co. , Ltd.
Molcoo Chemicals Inc.
MedBioPharmaceutical Technology Inc