Endoxifen
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- ₹0
- Product name: Endoxifen
- CAS: 112093-28-4
- MF: C25H27NO2
- MW: 373.49
- EINECS:
- MDL Number:
- Synonyms:(Z)-4-Hydroxy-N-desmethyl Tamoxifen;4-[(1Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol;Endoxifen;Phenol, 4-[(1Z)-1-[4-[2-(MethylaMino)ethoxy]phenyl]-2-phenyl-1-butenyl]-;(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer) see D292043;(Z)-4-Hydroxy-N-desmethyl Tamoxifen (contains up to 10% E isomer) ;(Z)-4-Hydroxy-N-DesMethyl TaMoxifen (Endoxifen);(Z)-Endoxifen
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Properties
Melting point :127-129°C
Boiling point :519.3±50.0 °C(Predicted)
Density :1.099±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -86°C Freezer, Under Inert Atmosphere
solubility :DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form :Powder
pka :10.36±0.15(Predicted)
color :White to off-white
Stability :Light Sensitive, Temperature Sensitive
Boiling point :519.3±50.0 °C(Predicted)
Density :1.099±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -86°C Freezer, Under Inert Atmosphere
solubility :DMSO : 50 mg/mL (133.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form :Powder
pka :10.36±0.15(Predicted)
color :White to off-white
Stability :Light Sensitive, Temperature Sensitive
Safety Information
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Description
Tamoxifen (TMX; ) is a selective estrogen receptor (ER) modulator used as adjuvant therapy for estrogen-dependent breast cancer. Endoxifen is an active metabolite of TMX, produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for ERs than TMX. As the efficient conversion of TMX to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.More related product prices
4-HYDROXYTAMOXIFEN 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine (E)-4-Acetoxy Tamoxifen Droloxifene TAMOXIFEN-N-OXIDE desdimethyltamoxifen 4Hydroxy Tamoxifen N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) TaMoxifen DiMer 4-Benzyloxy β-Hydroxy TaMoxifen N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) 15917-65-4 Tamoxifen citrate Afimoxifene (Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)-1-butene (E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen N-METHYL-N-(2-HYDROXYETHYL)TAMOXIFEN TamoxifenRelated product price
- 4-HYDROXYTAMOXIFEN
₹9380-60013.8 - 15917-65-4
₹28123.35 - Tamoxifen citrate
₹5880-128709.25
Suppliers and manufacturers
CLEARSYNTH LABS LTD.
SynZeal Research Pvt Ltd
Pharmaffiliates Analytics and Synthetics P. Ltd
Jiangxi Huihe Chemical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Chongqing Chemdad Co., Ltd
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.
