4Hydroxy Tamoxifen
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- Product name: 4Hydroxy Tamoxifen
- CAS: 82413-23-8
- MF: C26H29NO2
- MW: 387.51
- EINECS:
- MDL Number:
- Synonyms:4-[(1Z)-1-[[4-[2-(Dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]phenol;4'-Hydroxy TaMoxifen (contains up to 10% E isoMer);Phenol, 4-[(1Z)-1-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]propyl]-;Tamoxifen Citrate Impurity 13 (4'-Hydroxytamoxifen);4’-hydroxy Tamoxifen
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Properties
Melting point :150-153°C
Boiling point :514.4±50.0 °C(Predicted)
Density :1.092±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility :Chloroform (Slightly), Dichloromethane, Methanol (Slightly)
form :Solid
pka :10.32±0.15(Predicted)
color :White to Off-White
Stability :Light Sensitive
Boiling point :514.4±50.0 °C(Predicted)
Density :1.092±0.06 g/cm3(Predicted)
storage temp. :Amber Vial, -20°C Freezer, Under Inert Atmosphere
solubility :Chloroform (Slightly), Dichloromethane, Methanol (Slightly)
form :Solid
pka :10.32±0.15(Predicted)
color :White to Off-White
Stability :Light Sensitive
Safety Information
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Description
4’-hydroxy Tamoxifen is one of five main phase I metabolites of tamoxifen , a well-known estrogen receptor antagonist in breasts but partial estrogen receptor agonist in endometrium. 4’-hydroxy Tamoxifen is a product of cytochrome P450 (CYP)2D6 and CYP2B6 activity. With the addition of a hydroxyl group, 4’-hydroxy tamoxifen has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. At 10-100 μM, 4’-hydroxy tamoxifen is cytotoxic, in a non-apoptotic manner, to HEC-1B and HEC-1A human endometrial adenocarcinoma cell lines.More related product prices
2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine (E)-4-Acetoxy Tamoxifen Droloxifene TAMOXIFEN-N-OXIDE desdimethyltamoxifen Endoxifen N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture) TaMoxifen DiMer 4-Benzyloxy β-Hydroxy TaMoxifen N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) 4-HYDROXYTAMOXIFEN 15917-65-4 Tamoxifen citrate Afimoxifene (Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)-1-butene (E/Z)-N,N-Didesmethyl-4-hydroxy Tamoxifen N-METHYL-N-(2-HYDROXYETHYL)TAMOXIFENRelated product price
- 4-HYDROXYTAMOXIFEN
₹9380-60013.8 - 15917-65-4
₹28123.35 - Tamoxifen citrate
₹5880-128709.25
Suppliers and manufacturers
TargetMol Chemicals Inc.
Shenzhen Excellent Biomedical Technology Co.,Ltd.
Shenzhen Excellent Biomedical Technology Co., Ltd.
Cayman Chemical Company
Shanghai Yifei Biotechnology Co. , Ltd.
BOC Sciences
Shanghai YuZn Pharm. Technology Co.,Ltd.
TargetMol Chemicals Inc.
Toronto Research Chemicals
J & K SCIENTIFIC LTD.