antibiotic 1233A
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- ₹35960.65
- Product name: antibiotic 1233A
- CAS: 29066-42-0
- MF: C18H28O5
- MW: 324.41
- EINECS:
- MDL Number:
- Synonyms:1233A;Antibiotic F-244;F-244;L-659699;(R,R)-HyMeglusin;(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid;Hymeglusin;(2E, 4E, 7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0301
- Product descriptionHymeglusin ≥98% (HPLC), from Fusarium sp.
- Packaging1MG
- Price₹35960.65
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0301 | Hymeglusin ≥98% (HPLC), from Fusarium sp. | 1MG | ₹35960.65 | 2022-06-14 | Buy |
Properties
Boiling point :516.6±15.0 °C(Predicted)
Density :1.101±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :4.98±0.33(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Density :1.101±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :4.98±0.33(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
Hymeglusin is a fungal β-lactone antibiotic that inhibits HMG-CoA synthase (IC50 = 0.12 μM) by covalently modifying the active Cys129 residue of the enzyme. At a dose of 25 mg/kg, hymeglusin inhibits cholesterol biosynthesis in rats by 45%. Chiral studies indicate that the (2R,3R)-β-lactone moiety of hymeglusin is important for eliciting the specific inhibition of HMG-CoA synthase. As a cell-wall targeting antibiotic, hymeglusin has been used to investigate the role of a gene important for controlling S. aureus virulence in a mouse sepsis model of infection.Related product price
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