dendrobine
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- Product name: dendrobine
- CAS: 2115-91-5
- MF: C16H25NO2
- MW: 263.38
- EINECS:
- MDL Number:MFCD17676142
- Synonyms:(3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one;Dendroban-12-one;12-Oxodendrobane;7,5-(EpoxyMethano)-1H-cyclopent[cd]indol-9-one,decahydro-1,7b-diMethyl-6-(1-Methylethyl)-, (2aS,4aS,5R,6S,7R,7aS,7bR)-;Dendrobine Dendroban-12-one;Dendrobine 1%;Dendrobine, 98%, from Dendrobium nobile Lindl;Dendrobine 2115-91-5
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Properties
Melting point :135-136℃
Boiling point :375℃
Density :1.101
Flash point :133℃
storage temp. :4°C, protect from light
solubility :≥60mg/ml in MeOH
form :Powder
pka :9.49±0.60(Predicted)
color :White to yellow
Boiling point :375℃
Density :1.101
Flash point :133℃
storage temp. :4°C, protect from light
solubility :≥60mg/ml in MeOH
form :Powder
pka :9.49±0.60(Predicted)
color :White to yellow
Safety Information
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| Signal word: | Warning | |||||||
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Description
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.More related product prices
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