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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Anti-atherosclerotic Drugs >Ezetimibe

Ezetimibe

Ezetimibe Structure
  • ₹13314.75 - ₹22743.33
  • Product name: Ezetimibe
  • CAS: 163222-33-1
  • MF: C24H21F2NO3
  • MW: 409.43
  • EINECS:682-606-0
  • MDL Number:MFCD00937872
  • Synonyms:Ticagrelor and its interMediate;Ezetimibe 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one;zetia/vytorin;SCH 60969;Ezetimibe, >=99%;(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azeti;1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one;EZETIMIBE
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1629
  • Product descriptionEzetimibe ≥98% (HPLC)
  • Packaging25MG
  • Price₹13314.75
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1866
  • Product descriptionEzetimibe Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹22743.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1629 Ezetimibe ≥98% (HPLC) 25MG ₹13314.75 2022-06-14 Buy
Sigma-Aldrich(India) PHR1866 Ezetimibe Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹22743.33 2022-06-14 Buy

Properties

Melting point :164-166°C
alpha :D22 -33.9° (c = 3 in methanol)
Boiling point :654.9±55.0 °C(Predicted)
Density :1.334±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml)
pka :9.72±0.30(Predicted)
form :powder
color :White or off-white
BCS Class :2
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
InChIKey :OLNTVTPDXPETLC-XPWALMASSA-N
SMILES :N1(C2=CC=C(F)C=C2)[C@H](C2=CC=C(O)C=C2)[C@@H](CC[C@@H](C2=CC=C(F)C=C2)O)C1=O
CAS DataBase Reference :163222-33-1(CAS DataBase Reference)
EPA Substance Registry System :2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)- (163222-33-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Ezetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.It takes effect throughacting at the brush border of the small intestine and inhibiting the absorption of cholesterol, further leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of blood cholesterol.

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