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ChemicalBook > Product Catalogue >Natural Products >Lignans >Gomisin A

Gomisin A

Gomisin A Structure
  • ₹4800 - ₹14800
  • Product name: Gomisin A
  • CAS: 58546-54-6
  • MF: C23H28O7
  • MW: 416.47
  • EINECS:
  • MDL Number:MFCD01941645
  • Synonyms:2,3,13-tetramethoxy-l-stereoisomer ;benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-6-ol,5,6,7,8-tetrahydro-6,7-dimethy ;wuweizialcoholb ;wuweizichunb ;BESIGOMISIN;GOMISIN A;SCHISANDROL B;SCHIZANDROL B
2 prices
Selected condition:

Brand

  • TCI Chemicals (India)

Package

  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberG0537
  • Product descriptionGomisin A
  • Packaging5MG
  • Price₹4800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberG0537
  • Product descriptionGomisin A
  • Packaging25MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) G0537 Gomisin A 5MG ₹4800 2022-05-26 Buy
TCI Chemicals (India) G0537 Gomisin A 25MG ₹14800 2022-05-26 Buy

Properties

Melting point :88.5°C
Boiling point :454.79°C (rough estimate)
Density :1.1772 (rough estimate)
refractive index :1.5300 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form :powder to crystal
pka :14.58±0.40(Predicted)
color :White to Light yellow
LogP :4.770 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P501 Dispose of contents/container to..…

Description

Schisandrol B is a lignan originally isolated from S. chinensis that has hepatoprotective activity. It increases the expression of pregnane X receptor (PXR) target genes involved in bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver and CYP3A4, UGT1A1, and OATP2 in HEK293T cells. It also protects against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type, but not Pxr-null, mice and decreases mortality in a mouse model of cholestasis when administered at a dose of 100 mg/kg twice per day. It also promotes liver regeneration following partial hepatectomy and protects against hepatotoxicity induced by acetaminophen .

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