GSK484
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- ₹35874.05 - ₹137953.8
- Product name: GSK484
- CAS: 1652591-81-5
- MF: C27H32ClN5O3
- MW: 510.04
- EINECS:
- MDL Number:
- Synonyms:GSK484;GSK484 (hydrochloride);CS-2265;PAD4 inhibitor GS484;GSK484 HCl;((3S,4R)-3-amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride;AOB6992;GTPL8577
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1658
- Product descriptionGSK484 ≥98% (HPLC)
- Packaging5MG
- Price₹35874.05
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1658
- Product descriptionGSK484 ≥98% (HPLC)
- Packaging25MG
- Price₹137953.8
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1658 | GSK484 ≥98% (HPLC) | 5MG | ₹35874.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1658 | GSK484 ≥98% (HPLC) | 25MG | ₹137953.8 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
PBS buffer (pH 7.2):5.0(Max Conc. mg/mL);9.8(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.82(Max Conc. mM) form :powder
color :white to beige
Water Solubility :H2O: 2mg/mL, clear (warmed)
InChIKey :MULKOGJHUZTANI-JEGYXLSDNA-N
SMILES :C(C1CC1)N1C2=CC=CC=C2C=C1C1=NC2=CC(C(N3CC[C@@H](O)[C@@H](N)C3)=O)=CC(OC)=C2N1C.Cl |&1:22,24,r|
solubility :DMSO:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
Ethanol:25.0(Max Conc. mg/mL);49.01(Max Conc. mM)
PBS buffer (pH 7.2):5.0(Max Conc. mg/mL);9.8(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.82(Max Conc. mM) form :powder
color :white to beige
Water Solubility :H2O: 2mg/mL, clear (warmed)
InChIKey :MULKOGJHUZTANI-JEGYXLSDNA-N
SMILES :C(C1CC1)N1C2=CC=CC=C2C=C1C1=NC2=CC(C(N3CC[C@@H](O)[C@@H](N)C3)=O)=CC(OC)=C2N1C.Cl |&1:22,24,r|
Safety Information
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Description
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.More related product prices
6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide GSK481 GSK461364 GSK583 1346572-63-1 RET Kinase inhibitor 1 864082-47-3 GSK2636771 GSK2982772 GSK 2334470 GSK J4 HCl GSK864 1346574-57-9 188591-46-0 GSK2837808A GSK-2256098 942206-85-1 GSK 2033 GSK6853Related product price
- GSK 2334470
₹16672.2-67099.5 - GSK J4 HCl
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₹32085.3-125570
