HYDROXYFLUTAMIDE
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- ₹9800 - ₹56430.73
- Product name: HYDROXYFLUTAMIDE
- CAS: 52806-53-8
- MF: C11H11F3N2O4
- MW: 292.21
- EINECS:
- MDL Number:MFCD00563126
- Synonyms:2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid ;hydroxyniphtholide ;2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide;Hydroxy-Flutamide(Flutamide metabolite);5-Hydroxyflutamide, 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide, ;5-HYDROXYFLUTAMIDE;HYDROXYFLUTAMIDE (2-HYDROXY-2-METHYL-N-{4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL}PROPANAMIDE);α,α,α-Trifluoro-2-Methyl-4'-nitro-M- lactotoluidide
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberH1600
- Product descriptionHydroxyflutamide
- Packaging25MG
- Price₹9800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberH1600
- Product descriptionHydroxyflutamide
- Packaging100MG
- Price₹19600
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberH4166
- Product descriptionHydroxyflutamide ≥98% (HPLC)
- Packaging5MG
- Price₹14516.33
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberH4166
- Product descriptionHydroxyflutamide ≥98% (HPLC)
- Packaging25MG
- Price₹56430.73
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | H1600 | Hydroxyflutamide | 25MG | ₹9800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H1600 | Hydroxyflutamide | 100MG | ₹19600 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | H4166 | Hydroxyflutamide ≥98% (HPLC) | 5MG | ₹14516.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H4166 | Hydroxyflutamide ≥98% (HPLC) | 25MG | ₹56430.73 | 2022-06-14 | Buy |
Properties
Melting point :125-130°C
Boiling point :443.8±45.0 °C(Predicted)
Density :1.472
storage temp. :room temp
solubility :DMSO: >10mg/mL
form :powder
pka :12.87±0.70(Predicted)
color :white to tan
Boiling point :443.8±45.0 °C(Predicted)
Density :1.472
storage temp. :room temp
solubility :DMSO: >10mg/mL
form :powder
pka :12.87±0.70(Predicted)
color :white to tan
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC50 = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.Related product price
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