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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antiviral drugs >Nevirapine

Nevirapine

Nevirapine Structure
  • ₹9536.83 - ₹38829.28
  • Product name: Nevirapine
  • CAS: 129618-40-2
  • MF: C15H14N4O
  • MW: 266.3
  • EINECS:603-345-0
  • MDL Number:MFCD00866928
  • Synonyms:6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-;11-Cyclopropyl-4-Methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one;6H-Dipyrido[2,3-b:3',2'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-Methyl-;AIDS005653;BI-RG-587 & CD4-IgG;D00435;MLS00008458;N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 200MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberN0922
  • Product descriptionNevirapine min. 98.0 %
  • Packaging200MG
  • Price₹11500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0097
  • Product descriptionNevirapine
  • Packaging10MG
  • Price₹9536.83
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1757
  • Product descriptionNevirapine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹12080.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0097
  • Product descriptionNevirapine
  • Packaging50MG
  • Price₹38829.28
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) N0922 Nevirapine min. 98.0 % 200MG ₹11500 2022-05-26 Buy
Sigma-Aldrich(India) SML0097 Nevirapine 10MG ₹9536.83 2022-06-14 Buy
Sigma-Aldrich(India) PHR1757 Nevirapine Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹12080.7 2022-06-14 Buy
Sigma-Aldrich(India) SML0097 Nevirapine 50MG ₹38829.28 2022-06-14 Buy

Properties

Melting point :247°C
Boiling point :409.5°C (rough estimate)
Density :1.1300 (rough estimate)
refractive index :1.6200 (estimate)
Flash point :9℃
storage temp. :2-8°C
solubility :DMSO: ≥22mg/mL
form :powder
pka :2.8(at 25℃)
color :white to tan
Water Solubility :0.1g/L(temperature not stated)
Merck :14,6490
BCS Class :2
CAS DataBase Reference :129618-40-2(CAS DataBase Reference)
EPA Substance Registry System :6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl- (129618-40-2)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.

Description

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific allosteric inhibitors of HIV-1 reverse transcriptase. Nevirapine is an NNRTI that binds to viral reverse transcriptase and blocks polymerase activity by preventing RNA plus-strand initiation (IC50s = ~ 0.45 to 0.9 μM). It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV.

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