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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >AMPRENAVIR

AMPRENAVIR

AMPRENAVIR Structure
  • ₹12297.2 - ₹48896.53
  • Product name: AMPRENAVIR
  • CAS: 161814-49-9
  • MF: C25H35N3O6S
  • MW: 505.63
  • EINECS:827-179-5
  • MDL Number:MFCD00934214
  • Synonyms:KVX-478;AGENERASE;AMPRENAVIR;141W94;PROZEI;141W94, KVX-478, Agenerase, Prozei,;Carbamic acid, (1S,2R)-3-(4-aminophenyl)sulfonyl(2-methylpropyl)amino-2-hydroxy-1-(phenylmethyl)propyl-, (3S)-tetrahydro-3-furanyl ester;Angenerase
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0685
  • Product descriptionAmprenavir ≥98% (HPLC)
  • Packaging25MG
  • Price₹48896.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0685
  • Product descriptionAmprenavir ≥98% (HPLC)
  • Packaging5MG
  • Price₹12297.2
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0685 Amprenavir ≥98% (HPLC) 25MG ₹48896.53 2022-06-14 Buy
Sigma-Aldrich(India) SML0685 Amprenavir ≥98% (HPLC) 5MG ₹12297.2 2022-06-14 Buy

Properties

Melting point :72-74°C
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :11.54±0.46(Predicted)
color :white to beige
optical activity :[α]/D +8 to +12°, c = 0.5 in methanol
BCS Class :2
InChIKey :YMARZQAQMVYCKC-OEMFJLHTSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Amprenavir is a first generation inhibitor of the HIV-1 aspartic protease (Ki = 0.04 nM) that blocks replication of HIV-1 in the human T cell MT-4 cell line (IC50 = 150 nM) as well as in peripheral blood lymphocytes (IC50 = 80 nM). Through this action, it blocks the post-translational processing of gag and gag-pol gene products into key structural proteins and replication enzymes. When used alone or in combination therapy with other antiretroviral agents, amprenavir decreases viral load and increases CD4+ cell counts.

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