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ChemicalBook > Product Catalogue >API >Digestive system drugs >Cholagogue Drugs >Obeticholic Acid

Obeticholic Acid

Obeticholic Acid Structure
  • ₹8356.9 - ₹33958.03
  • Product name: Obeticholic Acid
  • CAS: 459789-99-2
  • MF: C26H44O4
  • MW: 420.63
  • EINECS:810-245-2
  • MDL Number:MFCD16621104
  • Synonyms:6alpha-Ethyl-chenodeoxycholic acid;6-Ecdca;6alph;6-Ethyl-cdca;C15636;6-Ethylchenodeoxycholic acid(Obeticholic Acid);Obeticholic Acid;(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-cholan-24-oic acid
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3096
  • Product descriptionObeticholic acid ≥98% (HPLC)
  • Packaging5MG
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML3096
  • Product descriptionObeticholic acid ≥98% (HPLC)
  • Packaging25MG
  • Price₹33730.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberCDS024140
  • Product description6-Ethylchenodeoxycholic acid
  • Packaging25MG
  • Price₹33958.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML3096 Obeticholic acid ≥98% (HPLC) 5MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) SML3096 Obeticholic acid ≥98% (HPLC) 25MG ₹33730.7 2022-06-14 Buy
Sigma-Aldrich(India) CDS024140 6-Ethylchenodeoxycholic acid 25MG ₹33958.03 2022-06-14 Buy

Properties

Melting point :108-110 °C
Boiling point :562.9±25.0 °C(Predicted)
Density :1.091
storage temp. :-20°C
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
form :White solid.
pka :4.76±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Obeticholic acid is a potent and selective farnesoid X receptor agonist that promotes the flow of bile in the liver. The drug was approved by the USFDA for the treatment of the rare chronic liver disease primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with inadequate response to UDCA or as a single agent therapy in adults unable to tolerate UDCA. Obeticholic acid was discovered at the Università de Perugia and developed by Intercept Pharmaceuticals. Obeticholic acid has also been granted orphan drug designation for the treatment of primary sclerosing cholangitis and primary biliary cirrhosis and has received breakthrough therapy designation for the treatment of patients with nonalcohol steatohepatitis (NASH) with liver fibrosis.

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