PD 0332991 HCl
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- ₹12940
- Product name: PD 0332991 HCl
- CAS: 827022-32-2
- MF: C24H30ClN7O2
- MW: 484
- EINECS:1592732-453-0
- MDL Number:MFCD22420809
- Synonyms:PD 0332991 HCl;PALBOCICLIB HCL; PD0332991 HCL;6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride Palbociclib (PD-0332991) HCl;Palbociclib hydrochloride, >=98%;PD-0332991 (Palbociclib);PD 0332991 hydrochloride;Palbociclib HCl;Palbociclib (hydrochloride)
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number5.30487
- Product descriptionStemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC?? = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk
- Packaging5MG
- Price₹12940
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 5.30487 | StemSelect PD 0332991 - CAS 827022-32-2 - Calbiochem A cell-permeable, brain permeant, potent, reversible, ATP competitive inhibitor of Cdk4 and Cdk6 (IC?? = 11, 9, and 15 nM for Cdk4/D1, Cdk4/D3 and Cdk | 5MG | ₹12940 | 2022-06-14 | Buy |
Properties
storage temp. := -70C
solubility :≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow liquid
color :Light yellow to yellow
solubility :≥14.48 mg/mL in H2O; ≥2.42 mg/mL in DMSO; ≥2.79 mg/mL in EtOH with gentle warming and ultrasonic
form :Yellow liquid
color :Light yellow to yellow
Safety Information
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Description
PD 0332991 is an orally active, selective inhibitor of the cyclin D kinases Cdk4 (IC50 = 11 nM) and Cdk6 (IC50= 16 nM) with no activity against a panel of 36 additional protein kinases. It has been reported to have antiproliferative activity against retinoblastoma-positive tumor cells, blocking retinoblastoma phosphorylation and inducing G1 arrest at nanomolar concentrations. PD 0332991 can inhibit the growth of certain ER-positive or HER2-amplified breast cancer cells (IC50s as low as 4 nM) and demonstrates synergy with tamoxifen and trastuzumab, respectively. Recently, PD 0332991 inhibition of Cdk4 activity has been used to demonstrate a role for insulin-activated cyclinD1-Cdk4 signaling in the control of glucose metabolism that is independent of cell cycle progression.More related product prices
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