SGC-GAK-1
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- ₹10684.28 - ₹43061.85
- Product name: SGC-GAK-1
- CAS: 2226517-76-4
- MF: C18H17BrN2O3
- MW: 389.24
- EINECS:
- MDL Number:MFCD31689258
- Synonyms:SGC-GAK-1;GAK INHIBITOR 1;6-Bromo-N-(3,4,5-trimethoxyphenyl)-4-quinolinamine;4-Quinolinamine, 6-bromo-N-(3,4,5-trimethoxyphenyl)-;6-Bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine;SGCGAK1,Inhibitor,SGC GAK 1,inhibit
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2202
- Product descriptionSGC-GAK-1 ≥98% (HPLC)
- Packaging5MG
- Price₹10684.28
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2202
- Product descriptionSGC-GAK-1 ≥98% (HPLC)
- Packaging25MG
- Price₹43061.85
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2202 | SGC-GAK-1 ≥98% (HPLC) | 5MG | ₹10684.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2202 | SGC-GAK-1 ≥98% (HPLC) | 25MG | ₹43061.85 | 2022-06-14 | Buy |
Properties
Boiling point :484.9±45.0 °C(Predicted)
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
pka :6.43±0.49(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Density :1.436±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
pka :6.43±0.49(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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Description
SGC-GAK-1 (2226517-76-4) is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD?= 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD?= 110 nM) and ADCK3 (KD?= 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50?= 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50?= 0.65 μM) and 22Rv1 (IC50?= 0.17 μM).Related product price
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