Valspodar
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- ₹18694.78 - ₹75233.75
- Product name: Valspodar
- CAS: 121584-18-7
- MF: C63H111N11O12
- MW: 1214.62
- EINECS:1312995-182-4
- MDL Number:MFCD00907207
- Synonyms:Valspodar;3'-Keto-bmt(1)-Val(2)-cyclosporin a;Cyclosporin A, 6-((R-(E))-6,7-didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid)-7-L-valine-;Sdz psc 833;Sdz-psc-833;Cyclo[[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl]-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl];6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoicacid]-7-L-valine-cyclosporinA;Valspodar(PSC-833,AMdray)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0572
- Product descriptionValspodar ≥98% (HPLC)
- Packaging5MG
- Price₹18694.78
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0572
- Product descriptionValspodar ≥98% (HPLC)
- Packaging25MG
- Price₹75233.75
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0572 | Valspodar ≥98% (HPLC) | 5MG | ₹18694.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0572 | Valspodar ≥98% (HPLC) | 25MG | ₹75233.75 | 2022-06-14 | Buy |
Properties
Melting point :143-145°C
alpha :D20 -255.1° (c = 0.5 in CHCl3)
Boiling point :1290.1±65.0 °C(Predicted)
Density :1.015±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.45±0.70(Predicted)
form :powder
color :white to beige
InChIKey :YJDYDFNKCBANTM-QCWCSKBGSA-N
alpha :D20 -255.1° (c = 0.5 in CHCl3)
Boiling point :1290.1±65.0 °C(Predicted)
Density :1.015±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :12.45±0.70(Predicted)
form :powder
color :white to beige
InChIKey :YJDYDFNKCBANTM-QCWCSKBGSA-N
Safety Information
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Description
PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine , daunorubicin , doxorubicin , and etoposide , respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin. PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.More related product prices
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