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Allisartan Isoproxil

Allisartan Isoproxil Structure
CAS No.
947331-05-7
Chemical Name:
Allisartan Isoproxil
Synonyms
Allisartan;Losartan Impurity N9;Allisartan Isoproxil;Allisartan Isoproxil, 10 mM in DMSO;Losartan Impurity 19（Allisartan Isoproxil）;1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester
CBNumber:
CB03159860
Molecular Formula:
C27H29ClN6O5
Molecular Weight:
553.01
MOL File:
947331-05-7.mol
Modify Date:
2024/11/12 8:58:12
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Allisartan Isoproxil Properties

Boiling point 745.0±70.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
pka 4.16±0.10(Predicted)
form Solid
color White to off-white

Allisartan Isoproxil Chemical Properties,Uses,Production

Clinical Use

Allisartan isoproxil, a member of a new class of selective angiotensin II-1 receptor antagonists, was approved by the Chinese Food and Drug Administration (CFDA) for the treatment of hypertension in July 2012.19 At time of publication, there is no trade name associated with this drug. Allisartan was discovered and developed by the Chinese biomedical company Allist Pharmaceuticals. Allisartan isoproxil is a prodrug which is readily hydrolyzed to active metabolite EXP3174, which is also the active metabolite of losartan (des-triphenylmethyl-9).

Synthesis

Although several synthetic routes have been reported within two patents, the most likely scalable process route is described in the scheme. Commercial 2-butyl-4-chloro-5-(hydroxymethyl)-imidazole (7) was alkylated with Ntriphenylmethyl- 5-(4'-bromomethylbiphenyl-2-yl)tetrazole (8) under basic conditions in warm DMF, providing alcohol 9 in 90% yield. This alcohol was then oxidized to the corresponding carboxylic acid 10 with KMnO4 in 88% yield. Etherification of acid 10 with isopropyl chloromethyl carbonate (11) followed by de-tritylation of the tetrazole group under acidic contidions gave allisartan isoproxil (II) in 69% yield.

Synthesis_947331-05-7

Allisartan Isoproxil Preparation Products And Raw materials

Raw materials

2-butyl-4-chloro-1-[(2'-(1-triphenylmethyl-1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl]imidazole-5-carboxylic acid 1-[(isopropoxy)carbonyloxy]methyl ester Chloromethyl isopropyl carbonate Losartan carboxylic acid

Preparation Products

Allisartan Isoproxil Suppliers

Global( 23)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3512 58 Inquiry
Shaanxi Didu New Material Co., Ltd 029-029-63373950 15353716720 China 9941 58 Inquiry
https://hanhongsci.com/ 021-54306202 18917919676 China 29998 58 Inquiry
Nanjing Chalf-Pharm Technology Co., Ltd. 025-57018978 18251899859 China 5765 50 Inquiry
Shanghai Xinlitai Pharmaceutical Co. , Ltd. 18616665298 China 234 58 Inquiry
guoyungurui 18162595016; 18162595016 China 10335 58 Inquiry
WEITIXIHAUGONG 0371-53370800 18037197114 China 10062 58 Inquiry
Cato Research Chemicals Inc. 020-81960175-877 18933936954 China 7764 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Hebei Miaoyin Technology Co.,Ltd 58
Shaanxi Didu New Material Co., Ltd 58
https://hanhongsci.com/ 58
Nanjing Chalf-Pharm Technology Co., Ltd. 50
Shanghai Xinlitai Pharmaceutical Co. , Ltd. 58
guoyungurui 58
WEITIXIHAUGONG 58
Cato Research Chemicals Inc. 58

Allisartan Isoproxil Spectrum

Allisartan Isoproxil(947331-05-7)1HNMR

947331-05-7(Allisartan Isoproxil)Related Search:

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Losartan potassium
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Allisartan Isoproxil 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, [[(1-methylethoxy)carbonyl]oxy]methyl ester Losartan Impurity 19（Allisartan Isoproxil） Allisartan Losartan Impurity N9 Allisartan Isoproxil, 10 mM in DMSO 947331-05-7