ZARDAVERINE

CAS No.: 101975-10-4

Chemical Name:: ZARDAVERINE

Synonyms: ZARDAVENINE;ZARDAVERINE;6-(4-(Difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one;6-[4-(DIFLUOROMETHOXY)-3-METHOXYPHENYL]-3(2H)-PYRIDAZINONE;3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one;3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one;3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]-

CBNumber:: CB1106730

Molecular Formula:: C12H10F2N2O3

Molecular Weight:: 268.22

MOL File:: 101975-10-4.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:54:58

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ZARDAVERINE Properties

Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO : 100 mg/mL (372.83 mM; Need ultrasonic)
form	Off-white to yellow solid.
pka	10.89±0.40(Predicted)
color	White to light yellow
CAS DataBase Reference	101975-10-4

SAFETY

Risk and Safety Statements

WGK Germany	3

ZARDAVERINE price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	Z3003	Zardaverine phosphodiesterase inhibitor	101975-10-4	5MG	₹13650.33	2022-06-14	Buy

Product number	Packaging	Price	Buy
Z3003	5MG	₹13650.33	Buy

ZARDAVERINE Chemical Properties,Uses,Production

Uses

Zardaverine can selectively inhibit?phosphodiesterase III (PDE III) from human platelets and?phosphodiesterase IV (PDE IV) from human polymorphonuclear leucocytes (PMN).

Definition

ChEBI: A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE3 and 4 (IC 50 values are 0.5 and 0.8 μ M respectively). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

ZARDAVERINE Preparation Products And Raw materials

Raw materials

Acetovanillone Hydrazine hydrate Glyoxylic acid monohydrate AMMONIUM

Preparation Products

ZARDAVERINE Suppliers

Global( 81)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Shanghai Tombiopharma Chemical Co. Ltd.	13391076197	China	4992	55	Inquiry
Shanghai Weiwei Biological Technology Co., Ltd.	021-55669583 18616258598	CHINA	4398	58	Inquiry
Shanghai Hao Biological Technology Co., Ltd.	021-80370006 13585899102	CHINA	6805	58	Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd.	15800340161	CHINA	6846	58	Inquiry
Shanghai Caiyou Industrial Co., Ltd.	021-34661276 18616021677	CHINA	6894	58	Inquiry

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Tombiopharma Chemical Co. Ltd.	55
Shanghai Weiwei Biological Technology Co., Ltd.	58
Shanghai Hao Biological Technology Co., Ltd.	58
Shanghai Hao Zhun Biological Technology Co., Ltd.	58
Shanghai Caiyou Industrial Co., Ltd.	58

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6-[4-(DIFLUOROMETHOXY)-3-METHOXYPHENYL]-3(2H)-PYRIDAZINONE ZARDAVERINE ZARDAVENINE 3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one 3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one 3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]- 6-(4-(Difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one 101975-10-4 C12H10F2N2O3 C12H10F2N3O3 Phosphodiesterase Inhibitors G Proteins and Cyclic Nucleotides Cyclic Nucleotide Metabolism Cell Signaling and Neuroscience Cell Biology BioChemical Cyclic Nucleotide related