CILOSTAMIDE

CAS No.: 68550-75-4

Chemical Name:: CILOSTAMIDE

Synonyms: OCP 3689;OPC 3689;CILOSTAMIDE;ciloalaMide;Cilostamide,OPC 3689;Cilostamide - CAS 68550-75-4 - Calbiochem;6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one;N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide;N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE;N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide

CBNumber:: CB1444199

Molecular Formula:: C20H26N2O3

Molecular Weight:: 342.43

MOL File:: 68550-75-4.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

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CILOSTAMIDE Properties

Melting point	186～188℃
Boiling point	594.3±50.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
storage temp.	0-6°C
solubility	Soluble in DMSO (up to 30 mg/ml).
form	White solid
pka	11.12±0.70(Predicted)
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
RIDADR	3249
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

CILOSTAMIDE price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C7971	Cilostamide phosphodiesterase inhibitor	68550-75-4	5MG	₹39500.43	2022-06-14	Buy
Sigma-Aldrich(India)	231085	Cilostamide - CAS 68550-75-4 - Calbiochem A cell-permeable selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC?? = 70 nM).	68550-75-4	10MG	₹27450.01	2022-06-14	Buy
ALFA India	ALF-J65319-MA	Cilostamide	68550-75-4	10mg	₹22027	2022-05-26	Buy

Product number	Packaging	Price	Buy
C7971	5MG	₹39500.43	Buy
231085	10MG	₹27450.01	Buy
ALF-J65319-MA	10mg	₹22027	Buy

CILOSTAMIDE Chemical Properties,Uses,Production

Uses

Cilostamide (OPC 3689) is a specific phosphodiesterase 3 (PDE3) inhibitor.

Biological Activity

Selective inhibitor of type III phosphodiesterase (PDE3). Displays moderate selectivity for PDE3A isozyme vs. PDE3B (IC 50 values are 0.027 and 0.050 μ M for PDE3A and PDE3B respectively). Inhibits ADP-induced platelet aggregation (IC 50 = 16.8 μ M); anti-thrombotic. Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC50 = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

CILOSTAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

dihydrocilostaMide

CILOSTAMIDE Suppliers

Global( 80)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6913	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Shanghai Weiwei Biological Technology Co., Ltd.	021-55669583 18616258598	CHINA	4398	58	Inquiry
Shanghai Haoyang Biological Technology Co., Ltd.	021-54046790 15121098156	CHINA	2905	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Alfa Aesar	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Weiwei Biological Technology Co., Ltd.	58
Shanghai Haoyang Biological Technology Co., Ltd.	58

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2-Hydroxy-6-methoxyquinoline 6-HYDROXYQUINOLINE 4-BUTOXYACETANILIDE

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OPC 3689 OCP 3689 N-CYCLOHEXYL-N-METHYL-4-(1,2-DIHYDRO-2-OXO-6-QUINOLYLOXY)BUTYRAMIDE CILOSTAMIDE Cilostamide,OPC 3689 ciloalaMide 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutanamide N-Cyclohexyl-4-[(1,2-dihydro-2-oxoquinolin-6-yl)oxy]-N-methylbutyramide N-cyclohexyl-4-[(2-hydroxyquinolin-6-yl)oxy]-N-methylbutanamide Cilostamide - CAS 68550-75-4 - Calbiochem Butanamide, N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl- N-Cyclohexyl-N-methyl-4-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)butanamide OPC-3689,OPC 3689,Cilostamide,Phosphodiesterase (PDE),Inhibitor,inhibit 68550-75-4 BioChemical Cell Biology Cell Signaling and Neuroscience Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides Cyclic Nucleotide related