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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Structure
CAS No.
85416-75-7
Chemical Name:
(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
Synonyms
CS-1181;(?)-Rolipram;(-)-Rolipram;(R)-(-)-ROLIPRAM;(S)-(+)-ROLIPRAM;Rolipram (R)-(-)-;(R)-(-)-Rolipram;(R)-ROLIPRAM;(-)-ROLIPRAM;4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone;(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
CBNumber:
CB2264846
Molecular Formula:
C16H21NO3
Molecular Weight:
275.34
MOL File:
85416-75-7.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Properties

Melting point 132.0 to 136.0 °C
Boiling point 472.7±45.0 °C(Predicted)
Density 1.155±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 16.02±0.40(Predicted)
form White to off-white solid.
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933.79.8500
HazardClass  IRRITANT

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) R0182 (R)-(-)-Rolipram 85416-75-7 10MG ₹7500 2022-05-26 Buy
TCI Chemicals (India) R0182 (R)-(-)-Rolipram 85416-75-7 50MG ₹26100 2022-05-26 Buy
Product number Packaging Price Buy
R0182 10MG ₹7500 Buy
R0182 50MG ₹26100 Buy

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties,Uses,Production

Uses

R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

(E)-2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene S- (+)-Rolipram Dimethyl malonate

Preparation Products

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Suppliers

Global( 91)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Clearsynth Labs 91-22-45045900 Maharashtra, India 3889 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Neostar United (Changzhou) Industrial Co., Ltd. +86-519-519-85557386 China 12330 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Alfa Chemistry United States 2344 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Supplier Advantage
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
Clearsynth Labs 58
Capot Chemical Co.,Ltd. 60
CONIER CHEM AND PHARMA LIMITED 58
Neostar United (Changzhou) Industrial Co., Ltd. 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Alfa Chemistry 58
InvivoChem 58

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(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (S)-(+)-ROLIPRAM (R)-(-)-ROLIPRAM (4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one Rolipram (R)-(-)- (4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (R)-(-)-Rolipram 4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone (R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one CS-1181 (R)-ROLIPRAM;(-)-ROLIPRAM 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- (?)-Rolipram (-)-Rolipram Inhibitor,inhibit,Phosphodiesterase (PDE),(R)()Rolipram,(R) ( ) Rolipram 85416-75-7 Signalling Cyclic Nucleotide related