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ZAPRINAST

CAS No.: 37762-06-4

Chemical Name:: ZAPRINAST

Synonyms: ZAPRINAST;M&B 22,948;M AND B 22948;M-EPSILON-TB22948;Phenylaza purinon;ZAPRINAST USP/EP/BP;Zaprinast (M&B 22948);3,6-dihydro-5-(2-propoxyphenyl)-;2-(o-Propoxyphenyl)-8-azapurin-6-one;8-Aza-2-(2-propoxyphenyl)-6-purinone

CBNumber:: CB3215496

Molecular Formula:: C13H13N5O2

Molecular Weight:: 271.27

MOL File:: 37762-06-4.mol

Modify Date:: 2023/6/30 15:45:59

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ZAPRINAST Properties

Melting point	237-238°C dec.
Density	1.48±0.1 g/cm3(Predicted)
RTECS	XZ6157358
storage temp.	Store at RT
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL
form	solid
pka	6.92±0.20(Predicted)
color	white
CAS DataBase Reference	37762-06-4

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

NFPA 704

	0
2		0

ZAPRINAST price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	Z0878	Zaprinast solid	37762-06-4	25MG	₹9113.1	2022-06-14	Buy
Sigma-Aldrich(India)	Z0878	Zaprinast solid	37762-06-4	100MG	₹29204.1	2022-06-14	Buy

Product number	Packaging	Price	Buy
Z0878	25MG	₹9113.1	Buy
Z0878	100MG	₹29204.1	Buy

ZAPRINAST Chemical Properties,Uses,Production

Chemical Properties

Zaprinast is Yellow-Orange Crystalline Powder

Uses

Zaprinast is a selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of at rial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC 50 values are 0.15, 0.76, 12.0 and 29.0 μ M respectively).

ZAPRINAST Preparation Products And Raw materials

Raw materials

Preparation Products

ZAPRINAST Suppliers

Global( 118)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Jiaxing Zhejia Biotechnology Co., LTD	0573-85609002	China	8873	58	Inquiry
Beijing Lebo Biotechnology Co., Ltd.	010-50934026	CHINA	6057	58	Inquiry
Zhengzhou convergence chemical co., LTD	0371-0371-55153829 18003835034	China	9357	58	Inquiry
TargetMol Chemicals Inc.	021-021-33632979 15002134094	China	7846	58	Inquiry
Nantong Feiyu Biological Technology CO.,LTD	0513-68819626; 13813788405	China	4821	58	Inquiry
Shanghai Yingxin laboratory equipment Co., Ltd	021-021-59178156 15300768757	China	10678	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
InvivoChem	58
Jiaxing Zhejia Biotechnology Co., LTD	58
Beijing Lebo Biotechnology Co., Ltd.	58
Zhengzhou convergence chemical co., LTD	58
TargetMol Chemicals Inc.	58
Nantong Feiyu Biological Technology CO.,LTD	58
Shanghai Yingxin laboratory equipment Co., Ltd	58

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EHNA HYDROCHLORIDE ZAPRINAST 2-ETHOXY-BENZAMIDINE 1H-[1,2,3]TRIAZOL-4-YLMETHYLAMINE HCL N-[(2-METHOXYPHENYL)METHYLENE]-N-METHYLAMINE

2-METHOXY-BENZAMIDINE HCL SALICYLALDEHYDE HYDRAZONE 2-PROPOXY-BENZAMIDINE

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1,4-DIHYDRO-5-[2-PROPOXYPHENYL]-7H-1,2,3-TRIAZOLO[4,5-D]PYRIMIDINE-7-ONE 2-(o-Propoxyphenyl)-8-azapurin-6-one 5-(2-propoxyphenyl)-2,3-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one 5-(2-propoxyphenyl)-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one 3,6-dihydro-5-(2-propoxyphenyl)- Zaprinast (M&B 22948) M AND B 22948 M-EPSILON-TB22948 2-(2-PROPYLOXYPHENYL)-8-AZAPURIN-6-ONE ZAPRINAST 2-(2-Propoxyphenyl)-6-hydroxy-8-azapurine 3,6-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one 8-Aza-2-(2-propoxyphenyl)-6-purinone M&B 22,948 1,4-dihydro-5-(2-propoxyphenyl)-7h-1,2,3-triazolo(4,5-d)pyrimidin-7-one 2-(2-Propoxyphenyl)-8-azahypoxanthine Phenylaza purinon Zaprinast - CAS 37762-06-4 - Calbiochem 5-(2-Propoxyphenyl)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-7(4H)-one 7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 3,6-dihydro-5-(2-propoxyphenyl)- ZAPRINAST USP/EP/BP 37762-06-4 C13H13N5O2 Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides Cell Biology Cell Signaling and Neuroscience BioChemical All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Cyclic Nucleotide related