ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >PDE inhibitors >ROLIPRAM
ROLIPRAM
- CAS No.
- 61413-54-5
- Chemical Name:
- ROLIPRAM
- Synonyms
- 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;ROLIPRAM;SB 95952;ZK-62711;Roliprame;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%;Rolipram Rolipram
- CBNumber:
- CB2703866
- Molecular Formula:
- C16H21NO3
- Molecular Weight:
- 275.34
- MOL File:
- 61413-54-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 127-133 °C |
|---|---|
| Boiling point | 418.29°C (rough estimate) |
| Density | 1.0677 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | H2O: 0.2 mg/mL |
| form | solid |
| pka | 16.02±0.40(Predicted) |
| color | white to off-white |
| Merck | 14,8251 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UY5749237 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29337900 | |||||||||
| Toxicity | LD50 oral in mouse: > 300mg/kg | |||||||||
| NFPA 704 |
|
ROLIPRAM price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R6520 | Rolipram solid, ≥98% (HPLC) | 61413-54-5 | 10MG | ₹21465.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R6520 | Rolipram solid, ≥98% (HPLC) | 61413-54-5 | 25MG | ₹38017.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R6520 | Rolipram solid, ≥98% (HPLC) | 61413-54-5 | 100MG | ₹124303.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 557330 | Rolipram - CAS 61413-54-5 - Calbiochem A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC?? = 800 nM). | 61413-54-5 | 5MG | ₹19050 | 2022-06-14 | Buy |
| TCI Chemicals (India) | R0110 | Rolipram | 61413-54-5 | 50MG | ₹10600 | 2022-05-26 | Buy |
ROLIPRAM Chemical Properties,Uses,Production
Chemical Properties
Yellowish solid
Uses
(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
General Description
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Biological Activity
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).
ROLIPRAM Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 187)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29797 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 15093356674; | China | 29826 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26925 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | China | 2996 | 58 | Inquiry |
61413-54-5(ROLIPRAM)Related Search:
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ROLIPRAM 98+%
Roliprame
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
SB 95952
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711
4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE
(R,S)-Rolipram
ZK-62711, SB95952, ME-3167
Rolipram, >=97%
ROLIPRAM
PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-)
ZK-62711
4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711
Rolipram - CAS 61413-54-5 - Calbiochem
Rolipram, 98%, a PDE4 inhibitor
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Rolipram - CAS 61413-54-5
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Rolipram Q: What is the CAS Number of
Rolipram Q: What is the storage condition of
Rolipram Q: What are the applications of
Rolipram
4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
Rolipram (ZK-62711)
61413-54-5
C16H21NO3
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Cyclic Nucleotide Metabolism
G Proteins and Cyclic Nucleotides
Phosphodiesterase Inhibitors
Inhibitor
DIPIPERON
Inhibitors
Antineoplastic
Cyclic Nucleotide related
Signalling