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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >PDE inhibitors >ROLIPRAM

ROLIPRAM

ROLIPRAM Structure
  • ₹10600 - ₹124303.48
  • Product name: ROLIPRAM
  • CAS: 61413-54-5
  • MF: C16H21NO3
  • MW: 275.34
  • EINECS:262-771-1
  • MDL Number:MFCD00270906
  • Synonyms:ROLIPRAM 98+%;Roliprame;2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-;SB 95952;4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711;4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE;(R,S)-Rolipram;ZK-62711, SB95952, ME-3167
Price6 Properties Safety Information Description
6 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • 100MG
  • 250MG
  • ManufacturerTCI Chemicals (India)
  • Product numberR0110
  • Product descriptionRolipram
  • Packaging50MG
  • Price₹10600
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberR0110
  • Product descriptionRolipram
  • Packaging250MG
  • Price₹20800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number557330
  • Product descriptionRolipram - CAS 61413-54-5 - Calbiochem A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC?? = 800 nM).
  • Packaging5MG
  • Price₹19050
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR6520
  • Product descriptionRolipram solid, ≥98% (HPLC)
  • Packaging10MG
  • Price₹21465.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR6520
  • Product descriptionRolipram solid, ≥98% (HPLC)
  • Packaging25MG
  • Price₹38017.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberR6520
  • Product descriptionRolipram solid, ≥98% (HPLC)
  • Packaging100MG
  • Price₹124303.48
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) R0110 Rolipram 50MG ₹10600 2022-05-26 Buy
TCI Chemicals (India) R0110 Rolipram 250MG ₹20800 2022-05-26 Buy
Sigma-Aldrich(India) 557330 Rolipram - CAS 61413-54-5 - Calbiochem A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC?? = 800 nM). 5MG ₹19050 2022-06-14 Buy
Sigma-Aldrich(India) R6520 Rolipram solid, ≥98% (HPLC) 10MG ₹21465.98 2022-06-14 Buy
Sigma-Aldrich(India) R6520 Rolipram solid, ≥98% (HPLC) 25MG ₹38017.4 2022-06-14 Buy
Sigma-Aldrich(India) R6520 Rolipram solid, ≥98% (HPLC) 100MG ₹124303.48 2022-06-14 Buy

Properties

Melting point :127-133 °C
Boiling point :418.29°C (rough estimate)
Density :1.0677 (rough estimate)
refractive index :1.5500 (estimate)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :H2O: 0.2 mg/mL
form :solid
pka :16.02±0.40(Predicted)
color :white to off-white
biological source :synthetic (organic)
Water Solubility :H2O: 0.2mg/mL
ethanol: 7mg/mL
DMSO: 7.3mg/mL Merck :14,8251
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Rolipram is a selective, cell-permeableinhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.

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