Progabide
- CAS No.
- 62666-20-0
- Chemical Name:
- Progabide
- Synonyms
- Gabren;Gabrene;SL-76．002;progabide;Halogabide;C-abren(e);Progabide USP/EP/BP;4-[α-(p-Chlorophenyl)-5-fluoro-2-hydroxybenzylideneamino]butyramide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide
- CBNumber:
- CB1296044
- Molecular Formula:
- C17H16ClFN2O2
- Molecular Weight:
- 334.77
- MOL File:
- 62666-20-0.mol
- Modify Date:
- 2023/9/4 15:51:00
| Melting point | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) |
|---|---|
| Boiling point | 525.4±50.0 °C(Predicted) |
| Density | 1.2822 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), DMSO, Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate) |
| color | Light Yellow to Yellow |
| Water Solubility | 37.16mg/L(37 ºC) |
| CAS DataBase Reference | 62666-20-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 i.p. in mice: 900 mg/kg (Kaplan) |
Progabide Chemical Properties,Uses,Production
Description
Progabide is a broad-spectrum anticonvulsant agent indicated for the treatment of a wide variety of seizure disorders. Synthesized as a GABA-prodrug, anticonvulsant activity appears due to the parent drug and its acid metabolite, as well as to GABAmide and GABA liberated therefrom.
Chemical Properties
Bright Yellow Solid
Uses
Progabide is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity.
World Health Organization (WHO)
Progabide, an anticonvulsant, was introduced in France in 1985 for the treatment of epilepsy. Its use has occasionally been associated with clinically evident signs of icteric hepatitis developing within the first six months of treatment. These signs are generally reversible on withdrawal of the drug but continuation of treatment has been associated with three reported fatalities (two of which are doubtfully related to the drug). The manufacturer revised the data sheet in March 1986 advising that use of progabide should be reserved for patients unresponsive to other anticonvulsants.
Progabide Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26063 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| Guangzhou Weijia Technology Co., Ltd. | 020-84224925 18300190102 | CHINA | 6748 | 58 | Inquiry |
| Shanghai Hao Biological Technology Co., Ltd. | 021-80370006 13585899102 | CHINA | 6805 | 58 | Inquiry |
| Shanghai Yubo Biotechnology Co., Ltd. | 021-51875103 15026509758 | CHINA | 6322 | 58 | Inquiry |