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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
CAS No.
6318-41-8
Chemical Name:
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms
PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K
CBNumber:
CB13232856
Molecular Formula:
C11H7NO4S
Molecular Weight:
249.24
MOL File:
6318-41-8.mol
MSDS File:
SDS
Modify Date:
2024/10/28 16:48:35
Request For Quotation

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Properties

Density 1.595±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 25 mg/ml).
form Yellow solid
pka 7.13±0.20(Predicted)
color Yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primaril 6318-41-8 5MG ₹15469.99 2022-06-14 Buy
Product number Packaging Price Buy
528114 5MG ₹15469.99 Buy

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties,Uses,Production

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers

Global( 21)Suppliers
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TargetMol Chemicals Inc. 58
InvivoChem 58
Focus Biomolecules 58
MedBioPharmaceutical Technology Inc 58
Cayman Chemical Company 81
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Tachizaki Biomedical Research Center 58
RD International Technology Co., Limited 58
InvivoChem 58
Henan Alpha Chemical Co., Ltd. 58

6318-41-8(2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-)Related Search:

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K 5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione 6318-41-8