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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
  • ₹15469.99
  • Product name: 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
  • CAS: 6318-41-8
  • MF: C11H7NO4S
  • MW: 249.24
  • EINECS:
  • MDL Number:MFCD18382117
  • Synonyms:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number528114
  • Product descriptionPI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primaril
  • Packaging5MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 528114 PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem The PI 3-Kγ Inhibitor VII, also referenced under CAS 6318-41-8, controls the biological activity of PI 3-Kγ. This small molecule/inhibitor is primaril 5MG ₹15469.99 2022-06-14 Buy

Properties

Density :1.595±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Yellow solid
pka :7.13±0.20(Predicted)
color :Yellow
Stability : Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
InvivoChem Focus Biomolecules MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc. Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. Shanghai Chaolan Chemical Technology Center Nantong QuanYi Biotechnology Co., Ltd Shanghai Tachizaki Biomedical Research Center