Citicoline sodium
- CAS No.
- 33818-15-4
- Chemical Name:
- Citicoline sodium
- Synonyms
- CITICOLINE;CITICOLINE SODIUM SALT;CITICOLINE MONOSODIUM SALT;GDPC;Logan;Brassel;Cidifos;Gerolin;Sinkron;Cebroton
- CBNumber:
- CB1343597
- Molecular Formula:
- C14H26N4O11P2.Na
- Molecular Weight:
- 511.31
- MOL File:
- 33818-15-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/11/13 18:13:23
| Melting point | 259-268°C (dec.) |
|---|---|
| alpha | D20 +12.5° (c = 1.0 in H2O) |
| storage temp. | -20°C |
| solubility | H2O: 100mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble in water (100 mg/ml). |
| λmax | 280nm(HCl aq.)(lit.) |
| Merck | 13,2343 |
| BRN | 4110040 |
| InChIKey | YWAFNFGRBBBSPD-OCMLZEEQSA-M |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O.[NaH] |&1:1,2,3,21,r| |
| CAS DataBase Reference | 33818-15-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 3-10-21 |
| HS Code | 29349990 |
Citicoline sodium price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C0256 | Cytidine 5′-diphosphocholine sodium salt dihydrate ~98%, from yeast, solid | 33818-15-4 | 100MG | ₹10002.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0256 | Cytidine 5′-diphosphocholine sodium salt dihydrate ~98%, from yeast, solid | 33818-15-4 | 500MG | ₹27679.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C0256 | Cytidine 5′-diphosphocholine sodium salt dihydrate ~98%, from yeast, solid | 33818-15-4 | 1G | ₹50769.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 30290 | Cytidine 5′-diphosphocholine sodium salt hydrate ≥99.0% (HPLC) | 33818-15-4 | 250MG | ₹11615.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 34015 | Citicoline sodium salt hydrate VETRANAL?, analytical standard | 33818-15-4 | 100MG | ₹10283.75 | 2022-06-14 | Buy |
Citicoline sodium Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.
Application
Citicoline (CDP-choline) is an essential intermediate in the synthesis of the major phospholipid of the cell membranes, phosphatidylcholine (PtdCho). It increases plasma adrenocorticotropic hormone (ACTH) levels and potentiates serum thyrotrophin (TSH) levels by activating the central cholinergic system.
Citicoline Sodium is used to treat age-related memory loss, cerebrovascular diseases such as stroke, dementia, as well as head trauma. Research has shown that it increases a chemical called phosphatidylcholine which is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured. Citicoline Sodium is also said to help with weight management when used as a dietary supplement.
General Description
Cytidine 5′-diphosphocholine (CDP-choline) contains cytidine and choline linked via a diphosphate bridge.
Side effects
Citicoline sodium may be safe for 12 weeks of oral use, side effects may include stomach pain, back pain, blurred vision, constipation and headache. While Citicoline 2% Eye Drops may be safe for long-term use (up to 3 years). No serious side effects have been reported by clinical investigators in the treatment of Parkinson's disease.
Safety
There are two forms of citicoline: citicoline sodium and citicoline free-base. Citicoline sodium is the form that is approved as a prescription medication in some European countries and throughout Asia. Citicoline free-base is the form that is available as a dietary supplement and food/beverage ingredient in the United States. In Europe, citicoline is approved as a Novel Food ingredient and is authorized to be used in food supplements up to 500 mg per day. It is also authorized to be used for Food for Special Medical Purposes (FSMPs) in amounts of 250 mg/serving and up to 1,000 mg per day.
Citicoline free-base is produced in Japan by Kyowa Hakko Bio Co. Ltd. under the brand name of Cognizin. Cognizin is considered to be safe and received self-designated Generally Recognized As Safe (GRAS) status in 2009. In Europe, citicoline was approved as a Novel Food ingredient in 2014. Whereas most companies produce citicoline synthetically, Cognizin is produced using a patented, natural fermentation process. It is vegetarian and allergen-free. Kyowa Hakko manufactures and supplies Cognizin as a raw ingredient to many manufacturers around the world.
Metabolism
Citicoline can be administered orally, intramuscularly, or intravenously. Oral administration is most common because its bioavailability is approximately 92%. After oral ingestion, citicoline is hydrolyzed in the small intestine and liver into 2 major metabolites: cytidine and choline.
Cytidine and choline enter the systemic circulation, where cytidine is further metabolized into uridine. Both uridine and free choline cross the blood-brain barrier. In the central nervous system, uridine is converted to cytidine triphosphate, choline is converted to phosphocholine, and the 2 combine to resynthesize CDP-choline.
Citicoline sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| Viruj Pharmaceuticals Pvt Ltd | +91-9441591589 +91-9441591589 | Hyderabad, India | 33 | 58 | Inquiry |
| SNECOFRi Pvt Ltd | +91-9032850129 +91-9032850129 | Telangana, India | 403 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Organo Chem (India) | +91-8459110412 +91-9810846377 | Uttar Pradesh, India | 21 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Chemino Pharma Ltd | +91-8689897373 +91-8689897373 | Maharashtra, India | 31 | 58 | Inquiry |
| SNJ Labs Pvt Ltd | +91-9033216399 +91-9824296655 | Gujarat, India | 17 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Salvavidas Pharmaceutical Pvt., Ltd. | +91-2612538898 +91-9327127459 | Gujarat, India | 34 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| Viruj Pharmaceuticals Pvt Ltd | 58 |
| SNECOFRi Pvt Ltd | 58 |
| AARTIA KEM SCIENCE | 58 |
| Organo Chem (India) | 58 |
| Bajaj Healthcare Ltd | 58 |
| Chemino Pharma Ltd | 58 |
| SNJ Labs Pvt Ltd | 58 |
| Aruvi Labs | 58 |
| Salvavidas Pharmaceutical Pvt., Ltd. | 58 |
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