Dipropylamine
- CAS No.
- 142-84-7
- Chemical Name:
- Dipropylamine
- Synonyms
- DPA;DI-N-PROPYLAMINE;DNPA;n,n-dipropylamine;ai3-24037;(n-C3H7)2NH;Di-n-propyL;DIPROPYLAMINE;Dipropanamine;AURORA KA-7671
- CBNumber:
- CB1713802
- Molecular Formula:
- C6H15N
- Molecular Weight:
- 101.19
- MOL File:
- 142-84-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:25
| Melting point | -63 °C |
|---|---|
| Boiling point | 105-110 °C(lit.) |
| Density | 0.738 g/mL at 25 °C(lit.) |
| vapor pressure | 38 hPa (20 °C) |
| refractive index |
n |
| Flash point | 39 °F |
| storage temp. | Store below +30°C. |
| solubility | 35g/l (experimental) |
| form | Liquid |
| pka | pK1:10.91(+1) (25°C) |
| color | Clear |
| explosive limit | 1.8-9.3%(V) |
| Water Solubility | soluble |
| Merck | 14,3343 |
| BRN | 505974 |
| Dielectric constant | 2.9（21℃） |
| Stability | Stable. Highly flammable. Incompatible with strong oxidizing agents. |
| LogP | 1.33 at 23℃ |
| Dissociation constant | 11 |
| CAS DataBase Reference | 142-84-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Propanamine, n-propyl-(142-84-7) |
| EPA Substance Registry System | Dipropylamine (142-84-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302-H311+H331-H314-H335 | |||||||||
| Precautionary statements | P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-20/21/22-35 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2383 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | JL9200000 | |||||||||
| Autoignition Temperature | 260 °C | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29211910 | |||||||||
| Toxicity | LD50 orally in rats: 0.93 g/kg, H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962) | |||||||||
| NFPA 704 |
|
Dipropylamine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 8.03548 | Dipropylamine for synthesis | 142-84-7 | 100ML | ₹2180 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D214752 | Dipropylamine 99% | 142-84-7 | 500ML | ₹4286.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D214752 | Dipropylamine 99% | 142-84-7 | 1L | ₹4827.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03548 | Dipropylamine for synthesis | 142-84-7 | 1L | ₹2670 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 8.03548 | Dipropylamine for synthesis | 142-84-7 | 500ML | ₹2800.01 | 2022-06-14 | Buy |
Dipropylamine Chemical Properties,Uses,Production
Chemical Properties
Dipropylamine, like the other short chain aliphatic amines, is a very strong base, its reactivity being governed by the unshared electron pair on the nitrogen atom. It forms a hydrate with water. The amine also can react with inorganic or organic nitrites under acidic conditions and possibly by reaction with nitrogen oxides from the air to form the highly mutagenic and carcinogenic N-nitrosodipropylamine (ATSDR 1979; Olah et al; Scanlan 1983).
Production Methods
Dipropylamine is manufactured by reaction of propanol and ammonia over a
dehydration catalyst at high temperature and pressure (HSDB 1989). Alternatively,
propanol and ammonia can be combined with hydrogen over a dehydrogenation
catalyst. In each instance, the resulting mixture of primary, secondary, and
tertiary amines can be separated by continuous distillation and extraction (Schweizer
et al 1978). Dipropylamine is a natural component of vegetables, fish, fruits,
and other foods (Mohri 1987) and of tobacco products (WHO 1987). It also is
found in human urine (Audunsson 1988), waste water lagoons (Guzewich et al
1983) and in workplace air (Simon and Lemacon 1987).
The toxic compound, N-nitrosodipropylamine, can be produced inadvertently
by nitrosation of n-dipropylamine during various manufacturing processes that use
the diamine (ATSDR 1989). The nitrosamine, therefore, occurs as an impurity in
some dinitroaniline pesticides and rubber products. N-nitrosodipropylamine also is
found in various foodstuffs including cheese, cured meats, cooked fish and
alcoholic beverages, apparently by reaction of n-dipropylamine with the preservative
sodium nitrite (ATSDR 1979; Gross and Newberne 1977; Scanlan 1983).
General Description
A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
Air & Water Reactions
Highly flammable. Soluble in water.
Reactivity Profile
Dipropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
Inhalation of dipropylamine vapors can result in severe coughing and chest pain due to irritation of airways. Transient symptoms of exposure may include headache, nausea, faintness, and anxiety. Prolonged breathing of vapors may result in lung edema. Dipropylamine also can cause severe irritation and edema of the cornea. A review of the toxicity of dipropylamine has been prepared (Anon 1987).
Fire Hazard
Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.
Industrial uses
Dipropylamine is used in the rubber industry and as a chemical intermediate in the manufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyl di-n-propylthiocarbamate (HSDB 1989). Dipropylamine also is employed in the purification of perfluoro compounds to convert the incompletely fluorinated impurities to solids which are then removed by filtration. In 1984, U.S. production was 41 million pounds.
Safety Profile
Poison by ingestion. Moderately toxic by shin contact and inhalation. A skin irritant. A very dangerous fire hazard, when exposed to heat or flame. Can react with oxidizers. Explosion hazard is unknown. Keep away from heat and open flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AMINES
Metabolism
There is little information available on the metabolism and disposition of dipropylamine
in biological systems. The available evidence suggests that dipropylamine
is not a substrate for monoamine oxidase, but rather is inhibitory. Valiev (1974)
administered dipropylamine intraperitoneally to rats and reported it to be moderately
inhibitory to liver monoamine oxidase. Previous work by this author demonstrated
that lethal doses of dipropylamine and other secondary and tertiary amines
significantly inhibited rat liver monoamine oxidase activity (Valiev 1968).
The carcinogenic N-nitrosodipropylamine has been detected in the stomach
when dipropylamine (present in fish, vegetables and fruit juices) comes in contact
with nitrite, which is often used as a food additive in meats and smoked fish
(HSDB 1989). Further metabolism of the carcinogen N-nitrosodipropylamine
product formed upon nitrosation of dipropylamine is required to form a highly
electrophilic carbonium ion capable of alkylating DNA, etc. (Archer 1981).
Dipropylamine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3753 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6202 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5870 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6905 | 58 | Inquiry |
| A. B. Enterprises | +91-8048077585 | Mumbai, India | 1394 | 58 | Inquiry |
| Arham Intermediates | 08047644206 | Mumbai, India | 41 | 58 | Inquiry |
| Bansari Enterprises | 08048361384Ext 162 | Maharashtra, India | 18 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| OCEAN TRADING CORPORATION | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| A. B. Enterprises | 58 |
| Arham Intermediates | 58 |
| Bansari Enterprises | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
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