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Vatalanib Dihydrochloride

Vatalanib Dihydrochloride Structure
CAS No.
212141-51-0
Chemical Name:
Vatalanib Dihydrochloride
Synonyms
PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber:
CB21176854
Molecular Formula:
C20H17Cl3N4
Molecular Weight:
419.74
MOL File:
212141-51-0.mol
Modify Date:
2025/4/17 18:22:24
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Vatalanib Dihydrochloride Properties

Melting point 268-2700C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form solid
color White or off-white
Water Solubility H2O: 2mg/mL, clear
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference 212141-51-0

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
Risk Statements  36/37/38
Safety Statements  24/25
HS Code  29333990

Vatalanib Dihydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2498 Vatalanib dihydrochloride ≥98% (HPLC) 212141-51-0 10MG ₹6689.85 2022-06-14 Buy
Sigma-Aldrich(India) SML2498 Vatalanib dihydrochloride ≥98% (HPLC) 212141-51-0 50MG ₹22526.83 2022-06-14 Buy
Product number Packaging Price Buy
SML2498 10MG ₹6689.85 Buy
SML2498 50MG ₹22526.83 Buy

Vatalanib Dihydrochloride Chemical Properties,Uses,Production

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Vatalanib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Vatalanib Dihydrochloride Suppliers

Global( 139)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Manus Aktteva +91 (79) 6512-3395 New Delhi, India 581 34 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 +8617705817739 China 52849 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Supplier Advantage
Manus Aktteva 34
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58

Vatalanib Dihydrochloride Spectrum

Vatalanib Dihydrochloride(212141-51-0)1HNMR

212141-51-0(Vatalanib Dihydrochloride)Related Search:

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Dihydrochloride Vatalanib succinate Vatalanib Dihydrochloride
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CGP-79787 Dihydrochlorid N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride Vatalanib Dihydrochloride CGP-79787 Dihydrochloride Vatalanib 2hcl((ZK-222584,PTK 787) Vatalanib dihydrochloride (PTK787) CGP-79787 CGP-79787D PTK/ZK ZK-222584 CGP-79787, PTK 787, ZK222584 N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride ZK 222584 (cpg-79787) 2HCl Vatalanib 2HCl (PTK787) Vatalanib (PTK787) 2HCl Vatalanib (hydrochloride) Vatalanib dihydrochloride(2HCL) Vatalanib (PTK787) diHydrochloride CS-465 ZK-222584 dihydrochloride CGP-797870 dihydrochloride PTK787 dihydrochloride Vatalanib Dihydrochloride USP/EP/BP 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2) CGP79787) 2HCl Vatalinib 2HCl Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor Vatalanib dihydrochloride, 10 mM in DMSO 212141-51-0 C20H17Cl3N4 C20H15ClN42HCl C20H15Cl2N42HCl C20H15ClN42ClH Heterocycles Tyrosine Kinase Inhibitors Antineoplastic Intermediates & Fine Chemicals Pharmaceuticals Inhibitors